Hypromellose acetate succinate

Base Information

• Chemical Name: Hypromellose acetate succinate
• CAS No.: 71138-97-1
• Molecular Formula: C10H22O9
• Molecular Weight: 0
• Hs Code.: 3912390000
• European Community (EC) Number: 615-255-9
• NCI Thesaurus Code: C83769,C83770
• RXCUI: 1313185,1376345,1426290,2645263
• Mol file: 71138-97-1.mol

Synonyms:HPMCAS;hydroxypropyl methylcellulose acetate succinate;hydroxypropylmethylcellulose acetate succinate;hypromellose acetate succinate

Chemical Property of Hypromellose acetate succinate

Chemical Property:

• Vapor Pressure: 0.0165mmHg at 25°C
• Boiling Point: 236.1°C at 760 mmHg
• Flash Point: 110.9°C
• PSA: 172.59000
• LogP: -1.00530
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Practically insoluble in ethanol (95%), hexane, unbuffered water, and xylene. On the addition of acetone, or a mixture of ethanol (95%) and dichloromethane (1 : 1), a clear or turbid viscous solution is produced. Hypromellose acetate succinate also forms a clear or turbid solution in buffers of pH greater than 4.5 with the rank order of solubility for the various grades increasing with the ratio of acetyl over succinoyl substitution. The exact pH value at which the polymer starts to swell and dissolve depends on the buffer type and ionic strength, although the rank order for the different grades is independent of the buffer used. No solvent has been found to completely dissolve hypromellose acetate succinate polymer; the resulting clear or turbid solutions significantly scatter light in both static and dynamic light scattering experiments, indicating that the polymer may exist as colloids or aggregates. The data is collated from the Shin-Etsu Chemical Co. Ltd and the research work of the authors (R Chen, BC Hancock, and RM Shanker).
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 286.12638228
• Heavy Atom Count: 19
• Complexity: 147

Purity/Quality:

98%, ^*data from raw suppliers

HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

• Canonical SMILES: CC(CO)O.CC(=O)O.CO.C(CC(=O)O)C(=O)O
• Uses: Hypromellose Acetate Succinate HPMCAS;is a pharmaceutical compound comprising enzalutamide.