1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine

Base Information

• Chemical Name: 1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine
• CAS No.: 112758-90-4
• Molecular Formula: C₁₄H₁₆N₂O
• Molecular Weight: 228.294
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90377894
• ChEMBL ID: CHEMBL1625832
• Mol file: 112758-90-4.mol

Synonyms:112758-90-4;1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine;1-(4-methoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine;F1386-0113;Oprea1_864721;CBDivE_006882;SCHEMBL2754345;CHEMBL1625832;DTXSID90377894;1-(4-methoxyphenyl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine;STK956582;AKOS000567981;AKOS016341307;BB 0221002;CS-0302794;EN300-235835

Chemical Property of 1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine

Chemical Property:

• Melting Point: 72-73 °C
• Boiling Point: 148-150 °C(Press: 2 Torr)
• PKA: 6.71±0.40(Predicted)
• PSA: 26.19000
• Density: 1.17±0.1 g/cm3(Predicted)
• LogP: 2.51810
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 228.126263138
• Heavy Atom Count: 17
• Complexity: 251

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Methoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2C3=CC=CN3CCN2

Technology Process of 1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine

There total 1 articles about 1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.4%

1-(4-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine (111609-58-6) → 1-(4-methyxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (112758-90-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1007/BF01145551

Reference yield:

[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid (766558-33-2) + 1-tert-butyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1020656-62-5) + 1-(2-thienyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (865546-35-6) + 1-(3-methoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1020657-11-7) + 1-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1020657-12-8) + 2-(2-(N-isobutyl-4-methoxy-2,3,6-trimethylphenylsulfonamide)ethoxy)-acetic acid (1021204-72-7) + 2-[2-[[(4-methoxy-2,3,6-trimethyl-phenyl)sulfonyl]-methyl-amino]-ethoxy]-acetic acid (1073556-99-6) + 1-(4-tert-butylphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1045520-22-6) + 1-(pyridine-3-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (865546-36-7) + 1-(6-chloropyridin-3-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1174068-53-1) + 1-(3,4-dimethylphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1174068-41-7) + 1-(3,4-difluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1105195-72-9) + N,N-dimethyl-1(1-(thiophen-2-yl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-6-yl)methanamine (1174068-51-9) + N,N-dimethyl-1-(1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)methanamine (1174068-44-0) + 1-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1174068-42-8) + 1-(2-fluoro-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1174068-43-9) + {2-[methyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-ethoxy}acetic acid (766558-35-4) + 1-phenyl-6-(pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1174068-45-1) + 2-[2-[benzyl-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-amino]-ethoxy]-acetic acid (1021205-10-6) + {2-[benzyl-(4-methoxy-2,3,6-trimethyl-benzenesulfonyl)-amino]-ethoxy}acetic acid (1021204-39-6) + 1-Methyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (73627-18-6) + 1-Phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (112758-89-1) + 1-(4-methyxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (112758-90-4) + tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazine (91476-80-1) → N-(2-(2-(1-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,4,6-tetramethylbenzenesulfonamide (1174283-09-0) + 4-methoxy-N,2,3,6-tetramethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide (1174282-70-2) + N,2,4,6-tetramethyl-N-(2-(2-oxo-2-(1-(pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide (1174283-11-4) + N-(2-(2-(1-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,3,5-tetramethylbenzenesulfonamide + N-(2-(2-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethoxy)ethyl)-N-isobutyl-4-methoxy-2,3,6-trimethylbenzenesulfonamide (1174282-63-3) + N-benzyl-4-methoxy-2,6-dimethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide (1174282-88-2) + 4-methoxy-N,2,3,5-tetramethyl-N-(2-(2-oxo-2-(1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide + 4-methoxy-N,2,3,5-tetramethyl-N-(2-(2-oxo-2-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide + N-(2-(2-(1-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,4,6-tetramethylbenzenesulfonamide (1174283-17-0) + N-benzyl-4-methoxy-2,3,6-trimethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide (1174282-82-6) + 4-methoxy-N-(2-(2-(1-(3-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,6-trimethylbenzenesulfonamide (1174283-06-7) + N-benzyl-N-(2-(2-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide (1174282-85-9) + N-(2-(2-(1-(6-chloropyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,3,6-tetramethylbenzenesulfonamide (1174282-72-4) + N-(2-(2-(1-(6-chloropyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,3,5-tetramethylbenzenesulfonamide + N-(2-(2-(1-(3,4-difluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,6-trimethylbenzenesulfonamide (1174283-01-2) + N-isobutyl-4-methoxy-2,3,6-trimethyl-N-(2-(2-oxo-2-(1-(pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide (1174282-60-0) + N-(2-(2-(1-(4-tert-butylphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,6-trimethylbenzenesulfonamide (1174283-08-9) + N-(2-(2-(6-((dimethylamino)methyl)-1-(thiophen-2-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,6-trimethylbenzene-sulfonamide (1174282-58-6) + N-(2-(2-(6-((dimethylamino)methyl)-1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,6-trimethylbenzenesulfonamide (1174282-54-2) + N-isobutyl-4-methoxy-N-(2-(2-(1-(4-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-2,3,6-trimethylbenzenesulfonamide (1174282-64-4) + 4-methoxy-N,2,3,5-tetramethyl-N-(2-(2-oxo-2-(1-(3-(trifluoromethyl)phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide + N-(2-(2-(1-(2-fluoro-4-(trifluoromethyl)phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,4,6-tetramethylbenzenesulfonamide (1174283-21-6) + N-benzyl-N-(2-(2-(1-(3,4-dimethylphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide (1174282-92-8) + N-benzyl-N-(2-(2-(1-(4-tert-butylphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide (1174282-94-0) + 4-methoxy-N,2,6-trimethyl-N-(2-(2-oxo-2-(1-phenyl-6-(pyrrolidin-1-ylmethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide (1174282-55-3)

Guidance literature:

[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid; 2-(2-(N-isobutyl-4-methoxy-2,3,6-trimethylphenylsulfonamide)ethoxy)-acetic acid; 2-[2-[[(4-methoxy-2,3,6-trimethyl-phenyl)sulfonyl]-methyl-amino]-ethoxy]-acetic acid; {2-[methyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-ethoxy}acetic acid; 2-[2-[benzyl-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-amino]-ethoxy]-acetic acid; {2-[benzyl-(4-methoxy-2,3,6-trimethyl-benzenesulfonyl)-amino]-ethoxy}acetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h; Combinatorial reaction / High throughput screening (HTS);

1-tert-butyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(2-thienyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(3-methoxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(3-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(4-tert-butylphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(pyridine-3-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(6-chloropyridin-3-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(3,4-dimethylphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(3,4-difluorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; N,N-dimethyl-1(1-(thiophen-2-yl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-6-yl)methanamine; N,N-dimethyl-1-(1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-6-yl)methanamine; 1-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-(2-fluoro-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-phenyl-6-(pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1-Methyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine; 1-Phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine; 1-(4-methyxyphenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazine; In dichloromethane; at 20 ℃; for 12h;

upstream raw materials:

1-(4-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine

Downstream raw materials:

N-(2-(2-(1-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,4,6-tetramethylbenzenesulfonamide

4-methoxy-N,2,3,6-tetramethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide

N,2,4,6-tetramethyl-N-(2-(2-oxo-2-(1-(pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide

N-(2-(2-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethoxy)ethyl)-N-isobutyl-4-methoxy-2,3,6-trimethylbenzenesulfonamide

Refernces