Ethanediamide, N-(2-methoxy-3-pyridinyl)-N-(1-methylethyl)-N'-[3-(trifluoromethyl)phenyl] -

Base Information

• Chemical Name: Ethanediamide, N-(2-methoxy-3-pyridinyl)-N-(1-methylethyl)-N'-[3-(trifluoromethyl)phenyl] -
• CAS No.: 112777-42-1
• Molecular Formula: C₁₈H₁₈F₃N₃O₃
• Molecular Weight: 381.354
• Mol file: 112777-42-1.mol

Synonyms:

Chemical Property of Ethanediamide, N-(2-methoxy-3-pyridinyl)-N-(1-methylethyl)-N'-[3-(trifluoromethyl)phenyl] -

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanediamide, N-(2-methoxy-3-pyridinyl)-N-(1-methylethyl)-N'-[3-(trifluoromethyl)phenyl] -

There total 3 articles about Ethanediamide, N-(2-methoxy-3-pyridinyl)-N-(1-methylethyl)-N'-[3-(trifluoromethyl)phenyl] - which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3-trifluoromethylaniline (98-16-8) + [Isopropyl-(2-methoxy-pyridin-3-yl)-amino]-oxo-acetyl chloride (112777-41-0) → N-(2-methoxy-3-pyridinyl)-N-(1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide (112777-42-1)

Guidance literature:

In tetrahydrofuran; for 4h;

DOI:10.1002/jhet.5570240403

Reference yield:

2-methoxy-3-nitropyridine (20265-35-4) → N-(2-methoxy-3-pyridinyl)-N-(1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide (112777-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / H₂ / sulfided platinum / ethanol / 8 h / 150 °C / 51714.8 Torr

2: tetrahydrofuran / 18 h / Ambient temperature

3: 58 percent / tetrahydrofuran / 4 h

With hydrogen; sulfided platinum; In tetrahydrofuran; ethanol;

DOI:10.1002/jhet.5570240403

Reference yield:

N-(1-methylethyl)-2-methoxy-3-aminopyridine (112777-37-4) → N-(2-methoxy-3-pyridinyl)-N-(1-methylethyl)-N'-(3-trifluoromethylphenyl)ethanediamide (112777-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 18 h / Ambient temperature

2: 58 percent / tetrahydrofuran / 4 h

In tetrahydrofuran;

DOI:10.1002/jhet.5570240403

upstream raw materials:

3-trifluoromethylaniline

[Isopropyl-(2-methoxy-pyridin-3-yl)-amino]-oxo-acetyl chloride

2-methoxy-3-nitropyridine

N-(1-methylethyl)-2-methoxy-3-aminopyridine

Refernces