6-CHLOROQUINOXALINE

Base Information

• Chemical Name: 6-CHLOROQUINOXALINE
• CAS No.: 5448-43-1
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.594
• Hs Code.: 2933990090
• Mol file: 5448-43-1.mol

Synonyms:6-Chloroquinoxaline;NSC 17797;

Chemical Property of 6-CHLOROQUINOXALINE

Chemical Property:

• Vapor Pressure: 0.00788mmHg at 25°C
• Melting Point: 295℃
• Refractive Index: 1.662
• Boiling Point: 276.9 °C at 760 mmHg
• PKA: -0.29±0.30(Predicted)
• Flash Point: 147.9 °C
• PSA: 25.78000
• Density: 1.349 g/cm³
• LogP: 2.28320
• Storage Temp.: Room temperature.

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloroquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 6-CHLOROQUINOXALINE

There total 5 articles about 6-CHLOROQUINOXALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinoxaline-N-oxide (6935-29-1) + potassium cyanide (151-50-8) → 2,3-diethynylquinoxaline (91-19-0) + 6-chloroquinoxaline (5448-43-1) + quinoxaline-6-carbonitrile (23088-24-6) + quinoxaline-2-carbonitrile (7483-33-2)

Guidance literature:

With benzoyl chloride; tetrabutyl-ammonium chloride; In chloroform; water; for 16h; Yield given. Further byproducts given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4020(01)85794-X

Reference yield:

quinoxaline-N-oxide (6935-29-1) → 2,3-diethynylquinoxaline (91-19-0) + 2-chloroquinoxaline (1448-87-9) + 6-chloroquinoxaline (5448-43-1) + quinoxaline-2-carbonitrile (7483-33-2)

Guidance literature:

With potassium cyanide; benzoyl chloride; In chloroform; water; for 0.5h; Yield given. Further byproducts given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4020(01)85794-X

Reference yield:

quinoxaline-N-oxide (6935-29-1) → 2-chloroquinoxaline (1448-87-9) + 6-chloroquinoxaline (5448-43-1) + 5-chloro-quinoxaline (62163-09-1) + 2-hydroxyquinoxaline (1196-57-2,144499-26-3)

Guidance literature:

With potassium cyanide; water; benzoyl chloride; In methanol; for 2h; Yield given. Further byproducts given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4020(01)85794-X

upstream raw materials:

quinoxaline-N-oxide

trimethylsilyl cyanide

potassium cyanide

Downstream raw materials:

6-chloro-quinoxaline 4-oxide

6-chloroquinoxaline-2,3(1H,4H)-dione

6-chloro-1,2,3,4-tetrahydroquinoxaline

6-chloroquinoxaline 1,4-dioxide

Refernces

• 1、 Nasielski-Hinkens, R.,Vyver, E. Vande,Nasielski, J.. "REGIOSELECTIVITY IN THE REACTION OF NITROQUINOXALINE-N-OXIDES WITH PHOSPHORYL CHLORIDE". . p. 663 - 670. Retrieved 2007/10/02.