5-AMINO-1-METHYL-3-PHENYLPYRAZOLE

Base Information

• Chemical Name: 5-AMINO-1-METHYL-3-PHENYLPYRAZOLE
• CAS No.: 10199-50-5
• Molecular Formula: C10H11N3
• Molecular Weight: 173.217
• Hs Code.: 2933199090
• Mol file: 10199-50-5.mol

Synonyms:(2-Methyl-5-phenyl-2H-pyrazol-3-yl)amine;1-Methyl-3-phenyl-5-aminopyrazole;3-Amino-2-methyl-5-phenyl-2H-pyrazole;5-Amino-1-methyl-3-phenylpyrazole;1-methyl-3-phenyl-1H-pyrazol-5-amine;

Chemical Property of 5-AMINO-1-METHYL-3-PHENYLPYRAZOLE

Chemical Property:

• Appearance/Colour: cream crystals
• Vapor Pressure: 1.3E-05mmHg at 25°C
• Melting Point: 125-128 °C
• Refractive Index: 1.624
• Boiling Point: 368.1 °C at 760 mmHg
• PKA: 3?+-.0.10(Predicted)
• Flash Point: 176.4 °C
• PSA: 43.84000
• Density: 1.17 g/cm³
• LogP: 2.25050
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methyl-3-phenyl-1H-pyrazol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-3-phenyl-1H-pyrazol-5-amine can be used to selectively target the TPX2 Site of Importin-?α Using Fragment-?Based Ligand Design.

Technology Process of 5-AMINO-1-METHYL-3-PHENYLPYRAZOLE

There total 16 articles about 5-AMINO-1-METHYL-3-PHENYLPYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Benzoylacetonitrile (614-16-4) + methylhydrazine (60-34-4) → 1-methyl-3-phenyl-1H-pyrazol-5-amine (10199-50-5)

Guidance literature:

In methanol; at 120 ℃; for 0.666667h; microwave irradiation;

DOI:10.1039/b611493h

Reference yield: 87.0%

5-azido-1-methyl-3-phenyl-1H-pyrazole (54962-76-4) → 1-methyl-3-phenyl-1H-pyrazol-5-amine (10199-50-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h; regioselective reaction;

DOI:10.1021/ol302418b

Reference yield: 74.0%

methyldiazene (22038-72-8,26981-93-1,51943-20-5) + Benzoylacetonitrile (614-16-4) → 1-methyl-3-phenyl-1H-pyrazol-5-amine (10199-50-5)

Guidance literature:

In methanol; at 120 ℃; for 0.666667h; Microwave irradiation;

upstream raw materials:

(Z)-3-chloro-3-phenyl-2-propenenitrile

methylhydrazine

methylhydrazine sulfate

Benzoylacetonitrile

Downstream raw materials:

1-methyl-3-phenyl-4-nitro-5-benzoylaminopyrazole

1-methyl-3-phenyl-4-amino-5-benzoylamidopyrazole

5-Amino-1-methyl-4-nitroso-3-phenylpyrazole

Refernces

• 1、 -. "HSP90 INHIBITORS AND USES THEREOF". Paragraph 00185; 00212. . Retrieved 2020/11/23.
• 2、 Behnke, Dirk,Cotesta, Simona,Hintermann, Samuel,Fendt, Markus,Gee, Christine E.,Jacobson, Laura H.,Laue, Grit,Meyer, Arndt,Wagner, Trixie,Badiger, Sangamesh,Chaudhari, Vinod,Chebrolu, Murali,Pandit, Chetan,Hoyer, Daniel,Betschart, Claudia. "Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)". . p. 5555 - 5560. Retrieved 2015/11/17.