2-FORMYL-5-NITROBENZOIC ACID

Base Information

• Chemical Name: 2-FORMYL-5-NITROBENZOIC ACID
• CAS No.: 7464-91-7
• Molecular Formula: C8H5NO5
• Molecular Weight: 195.131
• Hs Code.: 2918300090
• Mol file: 7464-91-7.mol

Synonyms:Phthalaldehydicacid, 5-nitro- (7CI,8CI);2-Carboxy-4-nitrobenzaldehyde;NSC 400132;2-formyl-5-nitrobenzoic acid;Benzoic acid, 2-formyl-5-nitro-;2-Formyl-5-nitrobenzoic acid;

Chemical Property of 2-FORMYL-5-NITROBENZOIC ACID

Chemical Property:

• Vapor Pressure: 5.65E-08mmHg at 25°C
• Refractive Index: 1.662
• Boiling Point: 424.8 °C at 760 mmHg
• Flash Point: 193.3 °C
• PSA: 100.19000
• Density: 1.555 g/cm³
• LogP: 1.62870

Purity/Quality:

99% ^*data from raw suppliers

AD051034:2-Formyl-5-nitro-benzoicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FORMYL-5-NITROBENZOIC ACID

There total 9 articles about 2-FORMYL-5-NITROBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-nitro-2-phenyl-inden-1-one (872823-31-9) → 2-formyl-5-nitrobenzoic acid (7464-91-7) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

bei der Ozonspaltung;

Reference yield:

6-nitrophthalide (610-93-5) → 2-formyl-5-nitrobenzoic acid (7464-91-7)

Guidance literature:

With chlorine; at 190 ℃; Irradiation_.UV-Licht; Erhitzen des Reaktionsprodukts mit Wasser;

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-bromo-5-nitrobenzoic acid (943-14-6) → 2-formyl-5-nitrobenzoic acid (7464-91-7)

Guidance literature:

2-bromo-5-nitrobenzoic acid; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.03.024

upstream raw materials:

6-nitrophthalide

6-nitro-2-phenyl-inden-1-one

sulfuric acid

o-carboxybenzaldehyde

Downstream raw materials:

1-benzyl-3,3-dimetyl-6'-nitrospiro(<2H-1>-benzopyran-2',2-indoline)

C₂₆H₂₄N₂O₃

4-nitrophthalic acid

C₂₇H₁₈N₂O₄

Refernces

• 1、 Wang, Baogang,Chai, Xiaoyun,Zhu, Weiwei,Wang, Ting,Wu, Qiuye. "A general approach to spirolactonized Si-rhodamines". . p. 14374 - 14377. Retrieved 2014/12/11.
• 2、 He, Yuwei,Cheng, Chuyu,Chen, Bin,Duan, Kun,Zhuang, Yue,Yuan, Bo,Zhang, Meisan,Zhou, Yougui,Zhou, Zihong,Su, Yu-Jun,Cao, Rihui,Qiu, Liqin. "Highly enantioselective synthesis of 2,3-dihydro-1 H-imidazo[2,1-a isoindol-5(9b H)-ones via catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization". supporting information. p. 6366 - 6369. Retrieved 2015/01/16.