N-(3-(Dimethylamino)propyl)methacrylamide

Base Information

• Chemical Name: N-(3-(Dimethylamino)propyl)methacrylamide
• CAS No.: 5205-93-6
• Deprecated CAS: 113263-70-0
• Molecular Formula: C9H18N2O
• Molecular Weight: 170.255
• Hs Code.: 29241990
• European Community (EC) Number: 226-002-3,266-635-2
• UNII: 63OBQ7BZDS
• DSSTox Substance ID: DTXSID7040154
• Nikkaji Number: J38.960I
• Wikidata: Q27263632
• Mol file: 5205-93-6.mol

Synonyms:DMAPMA compound;N-(3-(dimethylamino)propyl)methacrylamide

Chemical Property of N-(3-(Dimethylamino)propyl)methacrylamide

Chemical Property:

• Appearance/Colour: clear liquid
• Vapor Pressure: 0.000979mmHg at 25°C
• Melting Point: <-60 °C
• Refractive Index: n20/D 1.479(lit.)
• Boiling Point: 302.6 °C at 760 mmHg
• PKA: 15.01±0.46(Predicted)
• Flash Point: 136.8 °C
• PSA: 32.34000
• Density: 0.919 g/cm³
• LogP: 1.02130
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 170.141913202
• Heavy Atom Count: 12
• Complexity: 164

Purity/Quality:

99% ^*data from raw suppliers

N-[3-(Dimethylamino)propyl]methacrylamide99%,containsMEHQasinhibitor ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-38-43-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=C)C(=O)NCCCN(C)C

Technology Process of N-(3-(Dimethylamino)propyl)methacrylamide

There total 13 articles about N-(3-(Dimethylamino)propyl)methacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

2-(N,N-dimethylamino)ethanol (108-01-0) + 1-amino-3-(dimethylamino)propane (109-55-7) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → 2-(dimethylamino)ethyl methacrylate (2867-47-2) + 2-methyl-acrylic acid 3-dimethylamino-propyl amide (5205-93-6)

Guidance literature:

methacrylic acid methyl ester; With 10H-phenothiazine; 4-methoxy-phenol; Heating / reflux; Neat (no solvent);

di(n-butyl)tin oxide; at 70 - 101 ℃; Heating / reflux; Neat (no solvent);

2-(N,N-dimethylamino)ethanol; 1-amino-3-(dimethylamino)propane; titanium(IV) isopropylate; more than 3 stages; Product distribution / selectivity;

Reference yield: 95.0%

p-toluenesulfonic acid 3-dimethylamino-n-propyl ester (39743-22-1) + 2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) → 2-methyl-acrylic acid 3-dimethylamino-propyl amide (5205-93-6)

Guidance literature:

2-propenamide; With potassium hydroxide; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

p-toluenesulfonic acid 3-dimethylamino-n-propyl ester; In N,N-dimethyl-formamide; at 100 ℃; for 6h;

Reference yield: 93.0%

1-amino-3-(dimethylamino)propane (109-55-7) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → 2-methyl-acrylic acid 3-dimethylamino-propyl amide (5205-93-6)

Guidance literature:

methacrylic acid methyl ester; With 10H-phenothiazine; 4-methoxy-phenol; In xylene; at 70 ℃; Heating / reflux;

titanium(IV) isopropylate; di(n-butyl)tin oxide; In xylene; at 70 - 103 ℃; Heating / reflux;

1-amino-3-(dimethylamino)propane; In xylene; at 103 - 150 ℃; for 4h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

1-amino-3-(dimethylamino)propane

methacrylic acid methyl ester

1,2-propanediene

carbon monoxide

Downstream raw materials:

N,N-dimethyl-N-(3-sulfopropyl)-3'-methacrylamidopropanaminium inner salt

4-sulfonatobutyl[3-(methacryloylamino)propyl]dimethylammonium

Refernces

• 1、 -. "PREPARATION OF N,N-(DI)ALKYLAMINOALKYL(METH)ACRYLAMIDE OR N,N-(DI)ALKYLAMINOALKYL (METH)ACRYLATE AND THE QUATERNARY AMMONIUM SALTS THEREOF AS FLOCCULATING AIDS AND GELLING AGENTS". Paragraph 0081; 0088. . Retrieved 2018/02/01.
• 2、 -. "Continuous Method for Producing Amides of Ethylenically Unsaturated Carboxylic Acids". Page/Page column 9-10. . Retrieved 2011/05/03.