2-CHLORO-N,N-DIPHENYLACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N,N-DIPHENYLACETAMIDE
• CAS No.: 5428-43-3
• Molecular Formula: C14H12 Cl N O
• Molecular Weight: 245.708
• Hs Code.: 2924299090
• Mol file: 5428-43-3.mol

Synonyms:2-Chloro-N,N-diphenylacetamide;N,N-Diphenylchloroacetamide; N-(Chloroacetyl)-N-phenylaniline;N-(Chloroacetyl)diphenylamine; NSC 12965

Chemical Property of 2-CHLORO-N,N-DIPHENYLACETAMIDE

Chemical Property:

• Melting Point: 119-121°
• Boiling Point: 441.6°Cat760mmHg
• PKA: -4.03±0.50(Predicted)
• Flash Point: 220.8°C
• PSA: 20.31000
• Density: 1.234g/cm³
• LogP: 3.59010

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N,N-diphenylacetamide >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N,N-DIPHENYLACETAMIDE

There total 6 articles about 2-CHLORO-N,N-DIPHENYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diphenylamine (122-39-4) + chloroacetyl chloride (79-04-9) → 2-chloro-N,N-diphenylacetamide (5428-43-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

DOI:10.1021/acs.macromol.0c00412

Reference yield: 47.0%

diphenylamine (122-39-4) + chloroacetic acid (79-11-8) → 2-chloro-N,N-diphenylacetamide (5428-43-3)

Guidance literature:

With triethylamine; for 2h;

DOI:10.1021/jm900972u

Reference yield:

N,N-Diphenyl-N-(1,2-dichlorvinyl)amin (723-68-2) → 2-chloro-N,N-diphenylacetamide (5428-43-3)

Guidance literature:

With water;

DOI:10.1021/ja00869a021

upstream raw materials:

diphenylamine

chloroacetyl chloride

benzene

N,N-Diphenyl-N-(1,2-dichlorvinyl)amin

Downstream raw materials:

Diphenylamino-oxo-dithioacetic acid; compound with triethyl-amine

N,N-diphenyl-α-iodoacetamide

(2R,3S)-3-Phenyl-oxirane-2-carboxylic acid diphenylamide

Refernces

• 1、 Wang, Wenli,Zheng, Lan,Li, Wei,Zhu, Chen,Peng, Weiqing,Han, Bing,Fu, Wei. "Design, Synthesis, and Structure-Activity Relationship Studies of Novel Indolyalkylpiperazine Derivatives as Selective 5-HT1A Receptor Agonists". . p. 235 - 248. Retrieved 2020/02/18.
• 2、 Que, Chuqiang,Huang, Peipei,Yang, Zhanhui,Chen, Ning,Xu, Jiaxi. "Intramolecular carbene C-H insertion reactions of 2-diazo-2-sulfamoylacetamides". . . Retrieved 2019/08/01.