1,2-Bis(2-hydroxyethoxy)benzene

Base Information

• Chemical Name: 1,2-Bis(2-hydroxyethoxy)benzene
• CAS No.: 10234-40-9
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Hs Code.: 29094980
• European Community (EC) Number: 600-304-9
• DSSTox Substance ID: DTXSID20364878
• Nikkaji Number: J1.213.558K
• Wikidata: Q72501682
• Mol file: 10234-40-9.mol

Synonyms:10234-40-9;2,2'-(1,2-Phenylenebis(oxy))diethanol;1,2-Bis(2-hydroxyethoxy)benzene;2-[2-(2-hydroxyethoxy)phenoxy]ethanol;ethanol, 2,2'-[1,2-phenylenebis(oxy)]bis-;2-[2-(2-hydroxyethoxy)phenoxy]ethan-1-ol;O,O-BIS(2-HYDROXYETHOXY)BENZENE;O,O/'-BIS(2-HYDROXYETHOXY)BENZENE;Cambridge id 5116135;SCHEMBL238824;DTXSID20364878;HMS1578G11;1,2-bis(2-hydroxyethoxy) benzene;2,2-(1,2-phenylenedioxy)diethanol;MFCD00142719;AKOS003617545;2,2'-(1,2-Phenylenebisoxy)diethanol;2,2'-(o-Phenylenedioxy)diethanol, 97%;2-[2-(2-hydroxyethoxy)phenoxy]-1-ethanol;2,2'-[benzene-1,2-diylbis(oxy)]diethanol;FT-0744706;5-BroMo-4-chloro-2-fluoro-benzenesulfonylchloride

Chemical Property of 1,2-Bis(2-hydroxyethoxy)benzene

Chemical Property:

• Appearance/Colour: light beige crystalline powder
• Melting Point: 75-78 °C(lit.)
• Refractive Index: 1.5439 (estimate)
• Boiling Point: 355.9 °C at 760 mmHg
• PKA: 13.97±0.10(Predicted)
• Flash Point: 169 °C
• PSA: 58.92000
• Density: 1.197 g/cm³
• LogP: 0.42880
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 198.08920892
• Heavy Atom Count: 14
• Complexity: 124

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2′-(o-Phenylenedioxy)diethanol 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)OCCO)OCCO

Technology Process of 1,2-Bis(2-hydroxyethoxy)benzene

There total 14 articles about 1,2-Bis(2-hydroxyethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-<2-<(ethoxycarbonyl)methoxy>phenoxy>acetate (52376-09-7) → 2,2'-(1,2-phenylenedioxy)diethanol (10234-40-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Heating;

DOI:10.1021/jm00358a025

Reference yield: 99.0%

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) + 2-chloro-ethanol (107-07-3) → 2,2'-(1,2-phenylenedioxy)diethanol (10234-40-9)

Guidance literature:

With perhydrodibenzo-18-crown-6; In ethanol; for 2h; Product distribution; Heating; influence of different crown ethers, catalytic activity of crown ethers;

DOI:10.1007/BF00962671

Reference yield: 95.0%

oxirane (75-21-8,99932-75-9) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 2,2'-(1,2-phenylenedioxy)diethanol (10234-40-9)

Guidance literature:

With diethyl amine hydrochloride; at 30 - 35 ℃; for 240h;

DOI:10.1002/jhet.5570380142

upstream raw materials:

ethyl 2-<2-<(ethoxycarbonyl)methoxy>phenoxy>acetate

benzene-1,2-diol

2-chloro-ethanol

oxirane

Downstream raw materials:

dicinnamate of o-bis(3-hydroxy-1-oxa-propyl)benzene

2-(p-Dimethylaminophenyl)-7,8-benzo-1,3,6,9-tetraoxa-2-phosphacycloundecane

9-<4'-(benzo-18-crown-6)sulfonyl>-4,5-benzo-3,6,9-trioxa-1-nonanol

(3-Nitro-6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxa-benzocyclopentadecen-2-yl)-carbamic acid 2-[2-(2-hydroxy-ethoxy)-phenoxy]-ethyl ester

Refernces

• 1、 Ishikawa, Hiroki,Uemura, Naohiro,Taira, Ryo,Sano, Kento,Yoshida, Yasushi,Mino, Takashi,Kasashima, Yoshio,Sakamoto, Masami. "A new class of flavonoids bearing macrocyclic polyethers by stereoselective photochemical cycloaddition reaction". . p. 3911 - 3916. Retrieved 2019.
• 2、 Shu, Xi,Wang, Ruyu,Fan, Yu,Li, Shoujian,Huang, Chao. "Macrocyclic bis-urea receptor: Synthesis, crystal structure and phosphate binding properties". . p. 729 - 733. Retrieved 2019.
• 3、 Gilissen, Pieter J.,Swartjes, Anne,Spierenburg, Bram,Bruekers, Jeroen P.J.,Tinnemans, Paul,White, Paul B.,Rutjes, Floris P.J.T.,Nolte, Roeland J.M.,Elemans, Johannes A.A.W.. "Rapid and scalable synthesis of chiral porphyrin cage compounds". . p. 4640 - 4647. Retrieved 2019/07/12.