Cyclobutanecarboxylic acid, 1-[2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 1-[2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester
• CAS No.: 113239-54-6
• Molecular Formula: C17H20Cl2O4
• Molecular Weight: 359.249
• Mol file: 113239-54-6.mol

Synonyms:

Chemical Property of Cyclobutanecarboxylic acid, 1-[2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclobutanecarboxylic acid, 1-[2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester

There total 1 articles about Cyclobutanecarboxylic acid, 1-[2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',3'-dichloro-4'-hydroxybutyrophenone (2350-46-1) + ethyl 1-bromocyclobutane-1-carboxylate (35120-18-4) → 1-(4-Butyryl-2,3-dichloro-phenoxy)-cyclobutanecarboxylic acid ethyl ester (113239-54-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 55 - 60 ℃; for 16.5h;

DOI:10.1021/jm00131a008

Reference yield:

1-(4-Butyryl-2,3-dichloro-phenoxy)-cyclobutanecarboxylic acid ethyl ester (113239-54-6) → 1-(2,3-dichloro-4-butyrylphenoxy)cyclobutane-1-carboxylic acid (113239-53-5)

Guidance literature:

With hydrogenchloride; In acetic acid; Yield given; Heating;

DOI:10.1021/jm00131a008

Reference yield:

1-(4-Butyryl-2,3-dichloro-phenoxy)-cyclobutanecarboxylic acid ethyl ester (113239-54-6) → 1-<2,3-dichloro-4-(2-methylenebutyryl)phenoxy>cyclobutane-1-carboxylic acid (113239-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 5percent hydrochloric acid / acetic acid / Heating

2: 1.) Me₂NH*HCl / 1.) AcOH, steam bath, 7 h, 2.) DMF, 60 deg C, 1 h

With hydrogenchloride; N,N-dimethylammonium chloride; In acetic acid;

DOI:10.1021/jm00131a008

upstream raw materials:

2',3'-dichloro-4'-hydroxybutyrophenone

ethyl 1-bromocyclobutane-1-carboxylate

Downstream raw materials:

1-(2,3-dichloro-4-butyrylphenoxy)cyclobutane-1-carboxylic acid

1-<2,3-dichloro-4-(2-methylenebutyryl)phenoxy>cyclobutane-1-carboxylic acid

Refernces