2,4-Quinolinedicarboxylic acid, 8-methyl-3-phenyl-

Base Information

• Chemical Name: 2,4-Quinolinedicarboxylic acid, 8-methyl-3-phenyl-
• CAS No.: 113431-41-7
• Molecular Formula: C18H13NO4
• Molecular Weight: 307.306
• Mol file: 113431-41-7.mol

Synonyms:

Chemical Property of 2,4-Quinolinedicarboxylic acid, 8-methyl-3-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Quinolinedicarboxylic acid, 8-methyl-3-phenyl-

There total 1 articles about 2,4-Quinolinedicarboxylic acid, 8-methyl-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7-methyl-1H-indole-2,3-dione (1127-59-9) + 2-oxo-3-(phenyl)propionic acid (156-06-9) → 8-methyl-3-phenylquinoline-2,4-dicarboxylic acid (113431-41-7)

Guidance literature:

With sodium hydroxide; for 3h; Heating;

DOI:10.1021/jm00400a029

Reference yield: 77.0%

8-methyl-3-phenylquinoline-2,4-dicarboxylic acid (113431-41-7) → 8-methyl-3-phenylquinoline (113431-42-8)

Guidance literature:

With copper; at 270 - 280 ℃; for 0.25h;

DOI:10.1021/jm00400a029

Reference yield:

8-methyl-3-phenylquinoline-2,4-dicarboxylic acid (113431-41-7) → 3-phenylquinoline-8-carboxylic acid (113431-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / Cu / 0.25 h / 270 - 280 °C

2: 29 percent / SeO₂ / 270 - 290 °C

With selenium(IV) oxide; copper;

DOI:10.1021/jm00400a029

upstream raw materials:

7-methyl-1H-indole-2,3-dione

2-oxo-3-(phenyl)propionic acid

Downstream raw materials:

8-methyl-3-phenylquinoline

3-phenylquinoline-8-carboxylic acid

3-Phenyl-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride

Refernces