Nothofagin

Base Information

• Chemical Name: Nothofagin
• CAS No.: 11023-94-2
• Molecular Formula: C₂₁H₂₄O₁₀
• Molecular Weight: 436.416
• Mol file: 11023-94-2.mol

Synonyms:Nothofagin(8CI)

Chemical Property of Nothofagin

Chemical Property:

• PSA: 188.14000
• LogP: -0.16060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nothofagin 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nothofagin

There total 11 articles about Nothofagin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

UDP-glucose (133-89-1) + 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on (60-82-2) → 1-[3-(β-D-glucopyranosyl)-2,4,6-trihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one (11023-94-2)

Guidance literature:

With C-glycosyltransferase from Mangifera indica; In methanol; at 40 ℃; for 12h; pH=6.6; Enzymatic reaction;

DOI:10.1002/chem.201600411

Reference yield: 89.0%

C70H62O10 (1220779-37-2) → 1-[3-(β-D-glucopyranosyl)-2,4,6-trihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one (11023-94-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; for 2h; under 760.051 Torr;

DOI:10.1021/ol100315g

Reference yield: 78.8%

2'-hydroxy-3'-C-β-D-(2,3,4,6-tetra-O-benzylglucopyranosyl)-4,4',6'-tribenzyloxychalcone (169566-48-7) → 1-[3-(β-D-glucopyranosyl)-2,4,6-trihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one (11023-94-2)

Guidance literature:

With triethylsilane; 5%-palladium/activated carbon; In methanol; ethyl acetate; at 20 ℃; for 5h;

DOI:10.1021/acs.jmedchem.6b01134

upstream raw materials:

C₇₀H₆₂O₁₀

UDP-glucose

3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on

phloridizin

Refernces

• 1、 Liu, Hui,Tegl, Gregor,Nidetzky, Bernd. "Glycosyltransferase Co-Immobilization for Natural Product Glycosylation: Cascade Biosynthesis of the C-Glucoside Nothofagin with Efficient Reuse of Enzymes". . p. 2157 - 2169. Retrieved 2021.
• 2、 He, Jun-Bin,Zhao, Peng,Hu, Zhi-Min,Liu, Shuang,Kuang, Yi,Zhang, Meng,Li, Bin,Yun, Cai-Hong,Qiao, Xue,Ye, Min. "Molecular and Structural Characterization of a Promiscuous C-Glycosyltransferase from Trollius chinensis". supporting information. p. 11513 - 11520. Retrieved 2019/07/16.