Technology Process of 1H-Indole-2-carboxylic acid, 5-methyl-3-(1-methylethoxy)-1-phenyl-,
methyl ester
There total 3 articles about 1H-Indole-2-carboxylic acid, 5-methyl-3-(1-methylethoxy)-1-phenyl-,
methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: conc. sulfuric acid / 24 h / Heating
2: potassium t-butoxide / tetrahydrofuran / 2 h / Heating
3: potassium t-butoxide / dimethylsulfoxide / 30 h / Ambient temperature
4: K2CO3, CuBr, KOH, cupric acetate / 2 h / 135 - 140 °C
With
potassium hydroxide; sulfuric acid; potassium tert-butylate; copper diacetate; potassium carbonate; copper(I) bromide;
In
tetrahydrofuran; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium t-butoxide / dimethylsulfoxide / 30 h / Ambient temperature
2: K2CO3, CuBr, KOH, cupric acetate / 2 h / 135 - 140 °C
With
potassium hydroxide; potassium tert-butylate; copper diacetate; potassium carbonate; copper(I) bromide;
In
dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium t-butoxide / tetrahydrofuran / 2 h / Heating
2: potassium t-butoxide / dimethylsulfoxide / 30 h / Ambient temperature
3: K2CO3, CuBr, KOH, cupric acetate / 2 h / 135 - 140 °C
With
potassium hydroxide; potassium tert-butylate; copper diacetate; potassium carbonate; copper(I) bromide;
In
tetrahydrofuran; dimethyl sulfoxide;