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Technology Process of FTase Inhibitor I

FTase Inhibitor I

Base Information Edit
  • Chemical Name:FTase Inhibitor I
  • CAS No.:149759-96-6
  • Molecular Formula:C22H38 N4 O3 S2
  • Molecular Weight:470.69
  • Hs Code.:
  • DSSTox Substance ID:DTXSID30164381
  • Nikkaji Number:J701.579H
  • Wikidata:Q27157026
  • Pharos Ligand ID:MM4CWS1FW4BG
  • ChEMBL ID:CHEMBL91722
  • Mol file:149759-96-6.mol
FTase Inhibitor I

Synonyms:B 581;B-581;B581

Suppliers and Price of FTase Inhibitor I
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • FTaseInhibitorI
  • 1mg
  • $ 145.00
  • Sigma-Aldrich
  • B581 >95% (HPLC), solid
  • 1mg
  • $ 281.00
  • Chem-Impex
  • H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OHtrifluoroacetatesalt
  • 25MG
  • $ 2256.33
  • Cayman Chemical
  • FTase Inhibitor I ≥95%
  • 1mg
  • $ 112.00
  • Cayman Chemical
  • FTase Inhibitor I ≥95%
  • 500μg
  • $ 59.00
  • Biosynth Carbosynth
  • H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH trifluoroacetate salt
  • 2 mg
  • $ 289.00
  • Biosynth Carbosynth
  • H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH trifluoroacetate salt
  • 1 mg
  • $ 166.00
  • Biosynth Carbosynth
  • H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH trifluoroacetate salt
  • 500 ug
  • $ 95.00
  • Biosynth Carbosynth
  • H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH trifluoroacetate salt
  • 10 mg
  • $ 1003.50
  • Biosynth Carbosynth
  • H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH trifluoroacetate salt
  • 5 mg
  • $ 577.00
Total 9 raw suppliers
Chemical Property of FTase Inhibitor I Edit
Chemical Property:
  • Vapor Pressure:1.6E-21mmHg at 25°C 
  • Boiling Point:716.1°Cat760mmHg 
  • PKA:3.04±0.10(Predicted) 
  • Flash Point:386.9°C 
  • PSA：180.58000 
  • Density:1.161g/cm3 
  • LogP:3.25410 
  • Storage Temp.:−20°C 
  • Solubility.:H2O: soluble 
  • XLogP3:-0.1
  • Hydrogen Bond Donor Count:6
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:16
  • Exact Mass:470.23853343
  • Heavy Atom Count:31
  • Complexity:519
Purity/Quality:

98%Min *data from raw suppliers

FTaseInhibitorI *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 22-24/25 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC(C)C(CNC(CC1=CC=CC=C1)C(=O)NC(CCSC)C(=O)O)NCC(CS)N
  • Isomeric SMILES:CC(C)[C@@H](CN[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)O)NC[C@H](CS)N
  • Description FTase inhibitor I is a potent inhibitor of farnesyltransferase (FTase; IC50 = 21 nM) that is greater than 30-fold selective for FTase over geranylgeranyl transferase (GGTase; IC50 = 790 nM). It prevents farnesylation of Ras and inhibits proliferation of cells transformed by Ras farnesylation. In a dog model of subarachnoid hemorrhage, it reduces GTP-Ras in spastic basilar arteries, decreases angiographic vasospasm, and improves clinical scores.
  • Uses FTase Inhibitor I is a potent, selective, peptidomimetic FTase inhibitor.

Total 8 Pictures about this product

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