Pyrazine, 2-methoxymethyl-5-methyl-, 4-oxide

Base Information

• Chemical Name: Pyrazine, 2-methoxymethyl-5-methyl-, 4-oxide
• CAS No.: 83056-59-1
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.169
• Hs Code.: 2933990090
• European Community (EC) Number: 849-259-9
• DSSTox Substance ID: DTXSID20232149
• Nikkaji Number: J326.023B
• Wikidata: Q83113179
• ChEMBL ID: CHEMBL4303627
• Mol file: 83056-59-1.mol

Synonyms:83056-59-1;FCE 21990;Pyrazine, 2-methoxymethyl-5-methyl-, 4-oxide;2-Methoxymethyl-5-methylpyrazine 4-oxide;BRN 4980071;5-(METHOXYMETHYL)-2-METHYLPYRAZIN-1-IUM-1-OLATE;proacipimox;5-(methoxymethyl)-2-methyl-1-oxidopyrazin-1-ium;2-methoxymethyl-5-methylpyrazine-4-oxide;CHEMBL4303627;SCHEMBL10521047;DTXSID20232149;KKKHJYGCTVKQEM-UHFFFAOYSA-N;AKOS006278195;PD062308;LS-127619;EN300-253205;Z1198157805

Chemical Property of Pyrazine, 2-methoxymethyl-5-methyl-, 4-oxide

Chemical Property:

• Vapor Pressure: 0.000396mmHg at 25°C
• Boiling Point: 327°Cat760mmHg
• Flash Point: 151.6°C
• PSA: 47.58000
• Density: 1.14g/cm³
• LogP: 0.96490
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 154.074227566
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

2-METHOXYMETHYL-5-METHYLPYRAZINE 4-OXIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C=[N+]1[O-])COC

Technology Process of Pyrazine, 2-methoxymethyl-5-methyl-, 4-oxide

There total 7 articles about Pyrazine, 2-methoxymethyl-5-methyl-, 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-methoxymethyl-5-methylpyrazine (98502-93-3) → 2-methoxymethyl-5-methylpyrazine-4-oxide (83056-59-1)

Guidance literature:

With dihydrogen peroxide; In acetic acid; at 40 ℃; for 16h;

Reference yield:

2-hydroxymethyl-5-methylpyrazine-4-oxide (72788-71-7) → 2-methoxymethyl-5-methylpyrazine-4-oxide (83056-59-1)

Guidance literature:

With thionyl chloride; sodium methylate; sodium; zinc(II) chloride; In methanol; pentane; benzene;

Reference yield:

2-hydroxymethyl-5-methylpyrazine-4-oxide (72788-71-7) + methyl iodide (74-88-4) → 2-methoxymethyl-5-methylpyrazine-4-oxide (83056-59-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, r.t.; 2.) DMF, 2 h, r.t.;

upstream raw materials:

2-methoxymethyl-5-methylpyrazine

2-hydroxymethyl-5-methylpyrazine-4-oxide

methyl iodide

2,5-dimethyl-pyrazine

Refernces

• 1、 -. "Ethers of substituted hydroxymethylpyrazines". . . Retrieved 2008/06/13.