2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE

Base Information

• Chemical Name: 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE
• CAS No.: 6307-35-3
• Molecular Formula: C5H6BrN3O
• Molecular Weight: 204.026
• Hs Code.: 29335995
• Mol file: 6307-35-3.mol

Synonyms:4(1H)-Pyrimidinone,2-amino-5-bromo-6-methyl- (9CI);4-Pyrimidinol, 2-amino-5-bromo-6-methyl-(6CI);2-Amino-5-bromo-6-methyl-4-pyrimidinol;2-Amino-5-bromo-6-methyl-4-pyrimidinone;5-Bromo-6-methylisocytosine;NSC41319;U 25166;

Chemical Property of 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE

Chemical Property:

• Appearance/Colour: white to off-white powder
• Vapor Pressure: 0.00368mmHg at 25°C
• Melting Point: 244-246 °C(lit.)
• Refractive Index: 1.719
• Boiling Point: 280.9 °C at 760 mmHg
• PKA: 8.26±0.50(Predicted)
• Flash Point: 123.7 °C
• PSA: 72.03000
• Density: 2.04 g/cm³
• LogP: 1.41650

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-5-bromo-4-hydroxy-6-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Amino-5-bromo-6-methyl-4-pyrimidinol can be used as a precursor to novel GnRH receptor antagonists.

Technology Process of 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE

There total 6 articles about 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

5-bromo-1,3,6-trimethylpyrimidine-2,4(1 H,3H)-dione (15018-59-4) + guanidine nitrate (113-00-8) → 2-amino-5-bromo-6-methylpyrimidin-4(3H)-one (6307-35-3)

Guidance literature:

In ethanol; Heating;

Reference yield:

→ 2-amino-5-bromo-4-hydroxy-6-methylpyrimidine (6307-35-3)

Guidance literature:

2-Amino-4-hydroxy-6-methyl-pyrimidin, N-Brom-succinimid, Benzoylperoxid;

DOI:10.1246/bcsj.33.26

Reference yield:

2-amino-6-methyl-3H-pyrimidin-4-one (3977-29-5) → 2-amino-5-bromo-6-methylpyrimidin-4(3H)-one (6307-35-3)

Guidance literature:

With bromine; acetic acid;

DOI:10.1021/ja01209a019

upstream raw materials:

2-amino-6-methyl-3H-pyrimidin-4-one

5-bromo-1,3,6-trimethylpyrimidine-2,4(1 H,3H)-dione

guanidine nitrate

Downstream raw materials:

2,5-diamino-4-oxo-6-methyl pyrimidine

5-bromo-4-chloro-6-methylpyrimidin-2-ylamine

8H-imidazolo[1,2-α]pyrimid-5-one

methyl (2-amino-4-hydroxy-6-methylpyrimidin-5-yl)(phenyl)phosphinate

Refernces

• 1、 Wierenga,Skulnick,Stringfellow,Weed,Renis,Eidson. "5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents". . p. 237 - 239. Retrieved 2007/10/02.