4-chloro-2-methylbenzenesulfonyl chloride

Base Information

• Chemical Name: 4-chloro-2-methylbenzenesulfonyl chloride
• CAS No.: 56157-92-7
• Molecular Formula: C7H6Cl2O2S
• Molecular Weight: 225.095
• Hs Code.: 2904909090
• Mol file: 56157-92-7.mol

Synonyms:4-CHLORO-2-METHYLBENZENESULPHONYL CHLORIDE;4-Chloro-2-Methylbenzenesulfonyl Chloride;

Chemical Property of 4-chloro-2-methylbenzenesulfonyl chloride

Chemical Property:

• Vapor Pressure: 0.00271mmHg at 25°C
• Melting Point: 54 °C
• Refractive Index: 1.559
• Boiling Point: 295.3°Cat760mmHg
• Flash Point: 132.4°C
• PSA: 42.52000
• Density: 1.458g/cm³
• LogP: 3.65670

Purity/Quality:

98%min ^*data from raw suppliers

4-chloro-2-methylbenzenesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2-methylbenzenesulfonyl chloride

There total 3 articles about 4-chloro-2-methylbenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-chloro-3-methylbenzene (108-41-8) → 5-chloro-3-methylbenzene-2-sulphonyl chloride (56157-92-7)

Guidance literature:

With chlorosulfonic acid; thionyl chloride; at 0 - 20 ℃; for 20h;

DOI:10.3109/14756366.2015.1057722

Reference yield:

4-chloro-2-methylbenzeneamine (95-69-2) → 5-chloro-3-methylbenzene-2-sulphonyl chloride (56157-92-7)

Guidance literature:

4-chloro-2-methylbenzeneamine; With hydrogenchloride; acetic acid; sodium nitrite; In water; acetonitrile; at -10 - 5 ℃; for 0.166667h;

With sulfur dioxide; In water; acetonitrile; at 5 ℃; for 0.5h;

With copper dichloride; In water; acetonitrile; at 0 - 20 ℃;

Reference yield:

1-chloro-3-methylbenzene (108-41-8) → 5-chloro-3-methylbenzene-2-sulphonyl chloride (56157-92-7) + bis-(4-chloro, 2-methylphenyl) sulphone (132653-96-4)

Guidance literature:

With carbon disulfide; chlorosulphuric acid;

DOI:10.1039/jr9360000696

upstream raw materials:

1-chloro-3-methylbenzene

4-chloro-2-methylbenzeneamine

Downstream raw materials:

5-chloro-2-methyl-benzenesulfonamide

Refernces

• 1、 -. "THIOPHENE-2-CARBOXAMIDE DERIVATIVES AS MODULATORS OF CCR9 RECEPTOR". Page/Page column 52-53. . Retrieved 2009/05/29.