p-Nitro cinnamic acid

Base Information

• Chemical Name: p-Nitro cinnamic acid
• CAS No.: 619-89-6
• Molecular Formula: C9H7NO4
• Molecular Weight: 193.159
• Hs Code.: 29163990
• Mol file: 619-89-6.mol

Synonyms:Paranitrozimmtsaure;p-nitro cinnamic acid;4-nitro-cinnamic acid;(e)-4-nitrocinnamic acid;3-(4-nitrophenyl)-acrylic acid;3-(4-nitro-phenyl)-acrylic acid;AKOS017268922;FT-0619177;FT-0695132

Chemical Property of p-Nitro cinnamic acid

Chemical Property:

• Appearance/Colour: Off-white to belige powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 200-202 °C(lit.)
• Refractive Index: 1.655
• Boiling Point: 346 °C at 760 mmHg
• PKA: 4.07±0.10(Predicted)
• Flash Point: 153.9 °C
• PSA: 83.12000
• Density: 1.411 g/cm³
• LogP: 2.21580
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: DMSO
• Water Solubility.: insoluble
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 193.03750770
• Heavy Atom Count: 14
• Complexity: 248

Purity/Quality:

99% ^*data from raw suppliers

4-Nitrocinnamic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=CC(=O)O)[N+](=O)[O-]
• Uses: 4-Nitrocinnamic Acid (cas# 619-89-6) is a compound useful in organic synthesis.

Technology Process of p-Nitro cinnamic acid

There total 40 articles about p-Nitro cinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

cycl-isopropylidene malonate (2033-24-1) + 4-nitrobenzaldehdye (555-16-8) → p-nitrocinnamic acid (619-89-6)

Guidance literature:

With pomegranate juice; In water; at 20 ℃; for 0.25h; Reagent/catalyst; Sonication; Green chemistry;

DOI:10.1016/j.tetlet.2016.09.023

Reference yield: 98.0%

malonic acid (141-82-2) + 4-nitrobenzaldehdye (555-16-8) → p-nitrocinnamic acid (619-89-6)

Guidance literature:

pyrographite; In ethyl acetate; at 43 ℃; for 6h; ultrasound irradiation;

DOI:10.1081/SCC-100103251

Reference yield: 98.0%

p-nitrobenzene iodide (636-98-6) + acrylic acid (79-10-7) → p-nitrocinnamic acid (619-89-6)

Guidance literature:

With potassium carbonate; In water; for 0.833333h; Reflux; Green chemistry;

DOI:10.1002/aoc.4622

upstream raw materials:

4-isopropylcinnamic acid

2,3-dibromo-3-(4-nitro-phenyl)-propionic acid

acetic anhydride

4-nitrobenzaldehdye

Downstream raw materials:

methyl 4-nitrocinnamate

p-nitrocinnamic acid methyl ester

4-nitrostyrene

β-(trans-4-aminocyclohexyl)propionic acid

Refernces

• 1、 Zhang, Peng,Min, Zhihui,Gao, Yang,Bian, Jiang,Lin, Xin,He, Jie,Ye, Deyong,Li, Yilin,Peng, Chao,Cheng, Yunfeng,Chu, Yong. "Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia". . p. 7341 - 7358. Retrieved 2021/06/28.
• 2、 Xiao, Jian,Zhang, Haonan,Ejike, Anyaegbu Chima,Wang, Lu,Tao, Minli,Zhang, Wenqin. "Phenanthroline functionalized polyacrylonitrile fiber with Pd(0) nanoparticles as a highly active catalyst for the Heck reaction". . . Retrieved 2021/03/03.