2-AMINO-5-(4-AMYLPHENYL)-1,3,4-THIADIAZOLE

Base Information

• Chemical Name: 2-AMINO-5-(4-AMYLPHENYL)-1,3,4-THIADIAZOLE
• CAS No.: 114751-76-7
• Molecular Formula: C13H17N3S
• Molecular Weight: 247.35900
• Hs Code.: 2934999090
• Mol file: 114751-76-7.mol

Synonyms:

Chemical Property of 2-AMINO-5-(4-AMYLPHENYL)-1,3,4-THIADIAZOLE

Chemical Property:

• PSA: 80.04000
• LogP: 4.10120

Purity/Quality:

98%min ^*data from raw suppliers

5-(4-Pentyl-phenyl)-[1,3,4]thiadiazol-2-ylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-(4-AMYLPHENYL)-1,3,4-THIADIAZOLE

There total 3 articles about 2-AMINO-5-(4-AMYLPHENYL)-1,3,4-THIADIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-pentylbenzoic acid (26311-45-5) + thiosemicarbazide (79-19-6) → 5-(4-pentylphenyl)-1,3,4-thiadiazol-2-amine (114751-76-7)

Guidance literature:

With trichlorophosphate; at 0 - 70 ℃; for 4.5h;

DOI:10.3184/174751914X13990224465880

Reference yield:

C13H19N3OS (685541-11-1) → 5-(4-pentylphenyl)-1,3,4-thiadiazol-2-amine (114751-76-7)

Guidance literature:

With sulfuric acid; at 40 - 50 ℃; Yield given;

Reference yield:

4-pentylbenzoyl chloride (49763-65-7) → 5-(4-pentylphenyl)-1,3,4-thiadiazol-2-amine (114751-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / pyridine / Ambient temperature; left overnight

2: conc. H₂SO₄ / 40 - 50 °C

With pyridine; sulfuric acid;

upstream raw materials:

C₁₃H₁₉N₃OS

4-pentylbenzoyl chloride

4-pentylbenzoic acid

thiosemicarbazide

Downstream raw materials:

C₁₉H₂₀FN₅O₃S

2-(3-oxo-1,2-benzothiazol-2(3H)-yl)-N-(5-(4-pentylphenyl)-1,3,4-thiadiazol-2-yl)acetamide

2-(4-Pentyl-phenyl)-6-[4-(4-propyl-cyclohexyl)-phenyl]-imidazo[2,1-b][1,3,4]thiadiazole

6-(4-Butyl-phenyl)-2-(4-pentyl-phenyl)-imidazo[2,1-b][1,3,4]thiadiazole

Refernces

• 1、 Wan, Rong,Zhang, Jian-Qiang,Han, Fen,Wang, Peng,Yu, Peng,He, Qiu. "Synthesis and insecticidal activities of novel 1,3,4-thiadiazole 5-fluorouracil acetamides derivatives: An RNA interference insecticide". experimental part. p. 280 - 292. Retrieved 2012/02/03.