(2E)-3-(3,4-DIETHOXYPHENYL)ACRYLIC ACID

Base Information

• Chemical Name: (2E)-3-(3,4-DIETHOXYPHENYL)ACRYLIC ACID
• CAS No.: 137013-00-4
• Molecular Formula: C13H15O4-
• Molecular Weight: 236.268
• Mol file: 137013-00-4.mol

Synonyms:3-(3,4-Diethoxy-phenyl)-acrylic acid;3,4-diethoxy-trans-cinnamic acid;(E)-3-(3,4-Diethoxy-phenyl)-acrylic acid;3,4-Diaethoxy-trans-zimtsaeure;

Chemical Property of (2E)-3-(3,4-DIETHOXYPHENYL)ACRYLIC ACID

Chemical Property:

• Vapor Pressure: 8.72E-07mmHg at 25°C
• Boiling Point: 390.1°Cat760mmHg
• Flash Point: 146.5°C
• PSA: 55.76000
• Density: g/cm³
• LogP: 2.58180

Purity/Quality:

99%min ^*data from raw suppliers

(2E)-3-(3,4-diethoxyphenyl)prop-2-enoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-3-(3,4-DIETHOXYPHENYL)ACRYLIC ACID

There total 1 articles about (2E)-3-(3,4-DIETHOXYPHENYL)ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

malonic acid (141-82-2) + 3,4-diethoxybenzaldehyde (2029-94-9) → 3,4-diethoxycinnamic acid (137013-00-4)

Guidance literature:

With piperidine; pyridine; at 110 ℃; for 6h;

DOI:10.1007/BF00777420

Reference yield: 95.0%

3,4-diethoxycinnamic acid (137013-00-4) → 3-(3,4-diethoxyphenyl)propionic acid (79622-99-4)

Guidance literature:

With potassium hydroxide; hydrogen; nickel; at 60 ℃; for 3h; under 68400.1 Torr;

DOI:10.1007/BF00777420

Reference yield:

3,4-diethoxycinnamic acid (137013-00-4) → C13H15ClO3

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.molstruc.2017.09.110

upstream raw materials:

malonic acid

3,4-diethoxybenzaldehyde

Downstream raw materials:

3-(3,4-diethoxyphenyl)propionic acid

2-Dimethylaminomethyl-5,6-diethoxy-indan-1-one; hydrochloride

Refernces

• 1、 Daukshas, V. K.,Gaidyalis, P. G.,Labanauskas, L. K.,Gumbaragite, L. F.,Gasperavichene, G. A.. "SYNTHESIS OF 1,2-(DIMETHYLAMINOMETHYL-1-OXOPOLYMETHYLENE)BENZENES AND THEIR 4,5-DIETHOXY DERIVATIVES AND THEIR ANTI-INFLAMMATORY ACTIVITY". . p. 544 - 547. Retrieved 2007/10/02.