5-Heptenoic acid, 7-[(1R,2S,3S,4S)-3-[(phenylsulfonyl)amino]bicyclo[2.2.1]hept-2-yl]-, monosodium salt, (5Z)-

Base Information

• Chemical Name: 5-Heptenoic acid, 7-[(1R,2S,3S,4S)-3-[(phenylsulfonyl)amino]bicyclo[2.2.1]hept-2-yl]-, monosodium salt, (5Z)-
• CAS No.: 115267-11-3
• Molecular Formula: C₂₀H₂₆NO₄S*Na
• Molecular Weight: 399.487
• Mol file: 115267-11-3.mol

Synonyms:

Chemical Property of 5-Heptenoic acid, 7-[(1R,2S,3S,4S)-3-[(phenylsulfonyl)amino]bicyclo[2.2.1]hept-2-yl]-, monosodium salt, (5Z)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Heptenoic acid, 7-[(1R,2S,3S,4S)-3-[(phenylsulfonyl)amino]bicyclo[2.2.1]hept-2-yl]-, monosodium salt, (5Z)-

There total 14 articles about 5-Heptenoic acid, 7-[(1R,2S,3S,4S)-3-[(phenylsulfonyl)amino]bicyclo[2.2.1]hept-2-yl]-, monosodium salt, (5Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Domitroban (112966-96-8) → Sodium; (Z)-7-((1R,2S,3S,4S)-3-benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)-hept-5-enoate (115267-11-3)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1021/jm00117a028

Reference yield:

(4-carboxybutyl)triphenylphosphonium bromide (17814-85-6) → Sodium; (Z)-7-((1R,2S,3S,4S)-3-benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)-hept-5-enoate (115267-11-3)

Guidance literature:

Multi-step reaction with 6 steps

1: dimsylsodium / dimethylsulfoxide

2: diethyl ether

3: various solvent(s)

4: triethylamine / CH₂Cl₂

5: 1 N KOH / methanol

6: sodium methoxide / methanol

With potassium hydroxide; dimsylsodium; sodium methylate; triethylamine; In methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm00117a028

Reference yield:

benzenesulfonyl chloride (98-09-9) → Sodium; (Z)-7-((1R,2S,3S,4S)-3-benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)-hept-5-enoate (115267-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂

2: 1 N KOH / methanol

3: sodium methoxide / methanol

With potassium hydroxide; sodium methylate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jm00117a028

upstream raw materials:

Domitroban

(4-carboxybutyl)triphenylphosphonium bromide

benzenesulfonyl chloride

(1S,2S,3S,4R)-3-Allyl-bicyclo[2.2.1]hept-2-ylamine

Refernces