Technology Process of 2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)-
There total 9 articles about 2,4-Pyrimidinediamine, 5-((4-(aminomethyl)-3,5-dimethoxyphenyl)methyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
hydrogenchloride; methanol;
for 5h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 69 percent / sodium bis(2-methoxyethoxy)aluminum hyride, morpholine / toluene / 4 h / -15 °C
2: 73 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C
3: 59 percent / propan-2-ol / 0.5 h / Heating
4: 73 percent / sodium methylate / ethanol / 40 h / Heating
5: 55 percent / phosphorus oxychloride / pyridine / 3 h / 20 - 30 °C
6: 85 percent / H2 / Pd-C / aq. HCl; methanol / 5 h / Ambient temperature
With
morpholine; hydrogen; sodium methylate; sodium bis(2-methoxyethoxy)aluminium dihydride; trichlorophosphate;
palladium on activated charcoal;
In
pyridine; hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 73 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C
2: 59 percent / propan-2-ol / 0.5 h / Heating
3: 73 percent / sodium methylate / ethanol / 40 h / Heating
4: 55 percent / phosphorus oxychloride / pyridine / 3 h / 20 - 30 °C
5: 85 percent / H2 / Pd-C / aq. HCl; methanol / 5 h / Ambient temperature
With
hydrogen; sodium methylate; trichlorophosphate;
palladium on activated charcoal;
In
pyridine; hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;