Technology Process of Benzeneacetic acid, a-cyano-, 1,1-dimethylethyl ester
There total 3 articles about Benzeneacetic acid, a-cyano-, 1,1-dimethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenylacetonitrile;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 1h;
Inert atmosphere;
di-tert-butyl dicarbonate;
In
tetrahydrofuran;
at -78 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1021/ja2029602
- Guidance literature:
-
cyanoacetic acid tert-butyl ester;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -45 ℃;
for 0.75h;
Inert atmosphere;
benzoic acid anhydride;
In
tetrahydrofuran; hexane;
at -45 ℃;
for 1h;
Inert atmosphere;
DOI:10.1246/bcsj.20110307
- Guidance literature:
-
cyanoacetic acid tert-butyl ester;
With
potassium carbonate;
In
dimethyl sulfoxide;
for 0.5h;
phenyl donor;
In
dimethyl sulfoxide;
at 20 ℃;
for 12h;
DOI:10.1002/anie.202000138
