n-[(Benzyloxy)carbonyl]glycylserine

Base Information

• Chemical Name: n-[(Benzyloxy)carbonyl]glycylserine
• CAS No.: 4180-62-5
• Molecular Formula: C13H16 N2 O6
• Molecular Weight: 296.28
• Hs Code.: 2924299090
• NSC Number: 89631
• DSSTox Substance ID: DTXSID70293447
• Mol file: 4180-62-5.mol

Synonyms:4180-62-5;n-[(benzyloxy)carbonyl]glycylserine;Z-Gly-Ser-OH;3-hydroxy-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]propanoic acid;NSC89631;NCIOpen2_006161;DTXSID70293447;QJBVPDSNNNZVKZ-UHFFFAOYSA-N;NSC-89631;FT-0635174;2-hydroxy-2-methoxy acetic acid methyl ester;N-({[(benzyloxy)carbonyl]amino}acetyl)serine;N-(([(Benzyloxy)carbonyl]amino)acetyl)serine #;Propanoic acid, 3-hydroxy-2-[2-([benzyloxy)carbonyl]amino)acetyl)amino]

Chemical Property of n-[(Benzyloxy)carbonyl]glycylserine

Chemical Property:

• Vapor Pressure: 2.4E-17mmHg at 25°C
• Boiling Point: 641.7 °C at 760 mmHg
• Flash Point: 341.9 °C
• PSA: 124.96000
• Density: 1.374 g/cm³
• LogP: 0.25630
• Storage Temp.: -15°C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 296.10083623
• Heavy Atom Count: 21
• Complexity: 368

Purity/Quality:

99% ^*data from raw suppliers

Z-GLY-SER-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCC(=O)NC(CO)C(=O)O

Technology Process of n-[(Benzyloxy)carbonyl]glycylserine

There total 6 articles about n-[(Benzyloxy)carbonyl]glycylserine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + N-(N-benzyloxycarbonyl-glycyl)-L-serine methyl ester (108849-83-8,10239-27-7) → ethyl 2-(benzyloxycarbonylamino)ethanoate (1145-81-9) + N-benzyloxycarbonylglycylserine (4180-62-5) + N-(Benzyloxycarbonyl)glycine (1138-80-3) + Z-Gly-Ser-OEt

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In water; at 100 ℃; for 18h; Reagent/catalyst; Overall yield = 86 %Chromat.; Sealed tube;

DOI:10.1039/c6cc10300f

Reference yield:

N-(N-benzyloxycarbonyl-glycyl)-L-serine methyl ester (108849-83-8,10239-27-7) → N-benzyloxycarbonylglycylserine (4180-62-5)

Guidance literature:

With sodium hydroxide;

Reference yield:

benzyl (2-azido-2-oxoethyl)carbamate (50622-95-2) → N-benzyloxycarbonylglycylserine (4180-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate

2: aqueous methanol. NaOH

With sodium hydroxide; ethyl acetate;

upstream raw materials:

N-(N-benzyloxycarbonyl-glycyl)-L-serine methyl ester

L-serin

N-(benzyloxycarbonyl)glycyl chloride

Benzyloxycarbonylamino-acetic acid 5,5-dimethyl-3-oxo-cyclohex-1-enyl ester

Downstream raw materials:

Z-Gly-Ser-hydrazide

Refernces