4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride

Base Information

• Chemical Name: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride
• CAS No.: 116118-99-1
• Molecular Formula: C8H9NO2S.ClH
• Molecular Weight: 219.692
• Hs Code.: 2934999090
• Mol file: 116118-99-1.mol

Synonyms:4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid,hydrochloride;

Chemical Property of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride

Chemical Property:

• PSA: 77.57000
• LogP: 2.22280
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride

There total 1 articles about 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid diethyl ester (116119-00-7) → 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride (116118-99-1)

Guidance literature:

6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid diethyl ester; With potassium hydroxide; for 3h; Reflux;

With hydrogenchloride; In water; at 0 ℃; Product distribution / selectivity;

Reference yield: 95.0%

4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride (116118-99-1) → 4,5,6,7-tetrahydrothieno[3,2-c]pyridine (54903-50-3)

Guidance literature:

With sodium hydroxide; hydrogen bromide;

Reference yield: 50.0%

methanol (67-56-1) + 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride (116118-99-1) + di-tert-butyl dicarbonate (24424-99-5) → 5-(tert-butyl) 2-methyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate (1135123-74-8)

Guidance literature:

methanol; 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride; With thionyl chloride; at 0 ℃; Reflux;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; at 0 - 25 ℃; Product distribution / selectivity;

upstream raw materials:

6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid diethyl ester

Downstream raw materials:

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

5-(tert-butyl) 2-methyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate

6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester

Refernces