2-cyclopentylacetic acid

Base Information

• Chemical Name: 2-cyclopentylacetic acid
• CAS No.: 18322-54-8
• Molecular Formula: C9H16O2
• Molecular Weight: 156.225
• Mol file: 18322-54-8.mol

Synonyms:Ethylcyclopentaneacetate;Ethyl cyclopentylacetate;Ethylcyclopentylmethanecarboxylate;NSC 62679;

Chemical Property of 2-cyclopentylacetic acid

Chemical Property:

• Vapor Pressure: 0.396mmHg at 25°C
• Refractive Index: 1.446
• Boiling Point: 196.6 °C at 760 mmHg
• Flash Point: 66.6 °C
• PSA: 26.30000
• Density: 0.959 g/cm³
• LogP: 2.12980
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Ethyl 2-cyclopentylacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-cyclopentylacetic acid

There total 29 articles about 2-cyclopentylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl (2E)-7-iodohept-2-enoate (98202-45-0) → ethyl cyclopentylacetate (18322-54-8)

Guidance literature:

With nickel(II) iodide; samarium; diiodomethane; In tetrahydrofuran; tert-butyl alcohol; 1) -78 deg C, 30 min; 2) -78 deg C --> rt;

DOI:10.1021/jo971047e

Reference yield: 83.0%

(E)-ethyl 7-[(methylsulfonyl)oxy]hept-2-enoate (124668-81-1) → ethyl cyclopentylacetate (18322-54-8)

Guidance literature:

With tetrabutylammonium perchlorate; In N,N-dimethyl-formamide; electrolysis, platinum wire gauze anode, mercury pool cathode;

DOI:10.1016/S0040-4039(00)99641-2

Reference yield: 78.0%

diazoacetic acid ethyl ester (623-73-4) + Cyclopentane (287-92-3) → ethyl cyclopentylacetate (18322-54-8)

Guidance literature:

With C₁₉H₁₀BF₁₈N₈Zn⁽¹⁺⁾*ClO₄^(1-)*CH₂Cl₂; at 60 ℃;

DOI:10.1021/acs.inorgchem.5b02134

upstream raw materials:

diazoacetic acid ethyl ester

Cyclopentane

ethanol

2-cyclopentylacetyl chloride

Downstream raw materials:

(2-cyclopentylethene-1,1-diyl)dibenzene

1-Cyclopentyl-2,2-diphenyl-aethan

2-cyclopentylacetaldehyde

diethyl 2-cyclopentylmalonate

Refernces

• 1、 Molander, Gary A.,Harris, Christina R.. "Conjugate Addition Reactions Mediated by Samarium(II) Iodide". . p. 7418 - 7429. Retrieved 1997.
• 2、 Abas, Siti Nurdiana,Aguiar, Anna Caroline Campos,Ang, Xiaoman,Angulo-Barturen, I?igo,Blaquiere, Nicole,Bodenreider, Christophe,Campbell, Simon,Campo, Brice,Chan, Katherine,Chan, Wai Ling,Chen, Yen-Liang,Cooper, Roland A.,Crespo-Fernandez, Benigno,Diagana, Thierry T.,Ding, Mei,Fang, Eric,Gamo, Francisco Javier,Guiguemde, Armand,Huang, Richard,Jain, Jay Prakash,Jiménez-Díaz, María Belén,Kirrane, Tom,Lakshminarayana, Suresh B.,Lanshoeft, Christian,Lim, Jessie,Liu, Yugang,Mata, Anne-Catherine,Pei, Luying,Qumber, Jafri,Rosenthal, Philip J.,Sarko, Christopher,Schulz, Hanna,Shu, Wei,Sim, Sandra,Simon, Oliver,Straimer, Judith,Taft, Benjamin R.,Thompson, Christopher,Tumwebaze, Patrick,Vankadara, Subramanyam,Wagner, Jürgen,Waldron, Grace,Yokokawa, Fumiaki,Zou, Bin. "Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria". supporting information. p. 3798 - 3813. Retrieved 2022/03/16.
• 3、 Olmos, Andrea,Gava, Riccardo,Noverges, Bárbara,Bellezza, Delia,Jacob, Kane,Besora, Maria,Sameera, W. M. Chamil,Etienne, Michel,Maseras, Feliu,Asensio, Gregorio,Caballero, Ana,Pérez, Pedro J.. "Measuring the Relative Reactivity of the Carbon–Hydrogen Bonds of Alkanes as Nucleophiles". supporting information. p. 13848 - 13852. Retrieved 2018/09/06.