2-Acetoxybenzoic acid trimethylsilyl ester

Base Information

• Chemical Name: 2-Acetoxybenzoic acid trimethylsilyl ester
• CAS No.: 25436-28-6
• Molecular Formula: C₁₂H₁₆O₄Si
• Molecular Weight: 252.342
• Mol file: 25436-28-6.mol

Synonyms:Salicylicacid, trimethylsilyl ester, acetate (8CI); Silanol, trimethyl-, salicylateacetate (8CI); Edoferon KA; Trimethylsilyl acetylsalicylate

Chemical Property of 2-Acetoxybenzoic acid trimethylsilyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 2.60360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acetoxybenzoic acid trimethylsilyl ester

There total 2 articles about 2-Acetoxybenzoic acid trimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl-(7a-methyl-1,2,7-trioxa-cyclobuta[a]inden-2a-yloxy)-silane (129512-41-0) → Trimethylsilyl-2-acetoxybenzoat (25436-28-6)

Guidance literature:

In tetrachloromethane; at 35 ℃; for 1h;

DOI:10.1016/0040-4039(90)80200-6

Reference yield:

N,O-Bis(trimethylsilyl)trifluoroacetamide (25561-30-2) + aspirin (50-78-2,98201-60-6) → Trimethylsilyl-2-acetoxybenzoat (25436-28-6)

Guidance literature:

In acetonitrile; at 23 ℃; for 1h; Product distribution; effect time (1 - 60 min) and temperature (60 deg C) on the silylation of title compound for simultaneous determination with salicylic acid in plasma, serum and whole blood;

DOI:10.1002/jps.2600720935

upstream raw materials:

Trimethyl-(7a-methyl-1,2,7-trioxa-cyclobuta[a]inden-2a-yloxy)-silane

N,O-Bis(trimethylsilyl)trifluoroacetamide

aspirin

Refernces

• 1、 Adam,Kades,Wang. "Photooxygenation of 3- and 2-silyloxybenzofurans: Rearrangement of dioxetanes via α-silylperoxy ketones to ketoester cleavage products". . p. 2259 - 2262. Retrieved 2007/10/02.