4-Methyl-4'-hydroxydiphenyl sulfone

Base Information

• Chemical Name: 4-Methyl-4'-hydroxydiphenyl sulfone
• CAS No.: 7402-77-9
• Molecular Formula: C13H12 O3 S
• Molecular Weight: 248.302
• Mol file: 7402-77-9.mol

Synonyms:Phenol,p-(p-tolylsulfonyl)- (6CI,7CI,8CI); 4-Hydroxy-4'-methyldiphenyl sulfone;4-Methyl-4'-hydroxydiphenyl sulfone; NSC 400319; p-Hydroxyphenyl p-tolylsulfone

Chemical Property of 4-Methyl-4'-hydroxydiphenyl sulfone

Chemical Property:

• Vapor Pressure: 1.47E-08mmHg at 25°C
• Boiling Point: 445.7°C at 760 mmHg
• Flash Point: 223.4°C
• PSA: 62.75000
• Density: 1.289g/cm³
• LogP: 3.61420

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methyl-4'-hydroxydiphenyl sulfone

There total 23 articles about 4-Methyl-4'-hydroxydiphenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

toluene-4-sulfonic acid phenyl ester (640-60-8) → 4-tosylphenol (7402-77-9) + 2-[(4-methylphenyl)sulfonyl]phenol (10371-01-4)

Guidance literature:

With aluminium trichloride; for 0.0166667h; Irradiation;

Reference yield: 82.0%

bis<4-(p-tolylsulfonyl)phenyl> carbonate (138814-21-8) → 4-tosylphenol (7402-77-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 80 ℃; for 1h;

DOI:10.1021/jm00083a007

Reference yield: 78.0%

4-tolyl iodide (624-31-7) + (p-hydroxyphenyl)boronic acid (71597-85-8) → 4-tosylphenol (7402-77-9)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 4,4'-Dimethoxy-2,2'-bipyridin; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; at 110 ℃; for 36h;

DOI:10.1039/C6SC05483H

upstream raw materials:

4-methylphenyl-4-chlorophenyl sulfone

p-tolyl p-methoxyphenyl sulfone

toluene-4-sulfonic acid phenyl ester

pyridine hydrochloride

Downstream raw materials:

4-tosylphenyl acetate

4-(p-tolylsulfonyl)phenyl benzoate

p-tolyl p-methoxyphenyl sulfone

4-<(4-methoxyphenyl)sulfonyl>benzyl bromide

Refernces

• 1、 Phanindrudu, Mandalaparthi,Jaya, Pogula,Likhar, Pravin R.,Tiwari, Dharmendra Kumar. "Nano copper catalyzed synthesis of symmetrical/unsymmetrical sulfones from aryl/alkyl halides and p-toluenesulfonylmethylisocyanide: TosMIC as a tosyl source". . . Retrieved 2020/05/18.
• 2、 Yue, Huifeng,Zhu, Chen,Rueping, Magnus. "Cross-Coupling of Sodium Sulfinates with Aryl, Heteroaryl, and Vinyl Halides by Nickel/Photoredox Dual Catalysis". supporting information. p. 1371 - 1375. Retrieved 2018/01/27.