(2-methylphenyl)(2,4,6-trimethylphenyl)methanone

Base Information

• Chemical Name: (2-methylphenyl)(2,4,6-trimethylphenyl)methanone
• CAS No.: 1024-64-2
• Molecular Formula: C17H18 O
• Molecular Weight: 238.329
• Mol file: 1024-64-2.mol

Synonyms:Benzophenone,2,2',4,6-tetramethyl- (6CI,7CI,8CI); 2,2',4,6-Tetramethylbenzophenone;2,4,6,2'-Tetramethylbenzophenone; NSC 408642

Chemical Property of (2-methylphenyl)(2,4,6-trimethylphenyl)methanone

Chemical Property:

• Vapor Pressure: 0.000503mmHg at 25°C
• Boiling Point: 313.2°Cat760mmHg
• Flash Point: 129°C
• Density: 1.024g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-methylphenyl)(2,4,6-trimethylphenyl)methanone

There total 11 articles about (2-methylphenyl)(2,4,6-trimethylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-Methyl-benzoic acid methyl ester (89-71-4) + 1,3,5-trimethyl-benzene (108-67-8) → (2,4,6-trimethylphenyl)-(2-methylphenyl)-methanone (1024-64-2)

Guidance literature:

With iodine; phosphorus trichloride; In acetonitrile; at 160 ℃; Sealed tube; Schlenk technique;

DOI:10.1021/acs.joc.0c02794

Reference yield: 84.0%

mesitylboronic acid (5980-97-2) + 1-(2-methylbenzoyl)piperidine-2,6-dione → (2,4,6-trimethylphenyl)-(2-methylphenyl)-methanone (1024-64-2)

Guidance literature:

With palladium diacetate; sodium carbonate; tricyclohexylphosphine tetrafluoroborate; In 1,4-dioxane; at 120 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.9b02961

Reference yield: 84.0%

2-methylbenzotrifluoride (13630-19-8) + 1,3,5-trimethyl-benzene (108-67-8) → (2,4,6-trimethylphenyl)-(2-methylphenyl)-methanone (1024-64-2)

Guidance literature:

2-methylbenzotrifluoride; 1,3,5-trimethyl-benzene; With boron tribromide; In dichloromethane; at 25 ℃; for 3h; Inert atmosphere;

With methanol; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.202001816

upstream raw materials:

ortho-toluoyl chloride

1,3,5-trimethyl-benzene

ortho-tolylmagnesium bromide

mesitylene-2-carboxylic acid chloride

Downstream raw materials:

Mesityl-o-tolyl-methanol

methyl-(2,4,6,2'-tetramethyl-benzhydryl)-ether

2,4,6,2'-Tetramethyl-benzhydrol

Refernces

• 1、 Xiao, Jing,Guo, Fengzhe,Li, Yinfeng,Li, Fangshao,Li, Qiang,Tang, Zi-Long. "Iodine Promoted Conversion of Esters to Nitriles and Ketones under Metal-Free Conditions". . p. 2028 - 2035. Retrieved 2021/02/03.
• 2、 Tran, Phuong Hoang,Hansen, Poul Erik,Nguyen, Hai Truong,Le, Thach Ngoc. "Erbium trifluoromethanesulfonate catalyzed Friedel-Crafts acylation using aromatic carboxylic acids as acylating agents under monomode-microwave irradiation". . p. 612 - 618. Retrieved 2015/02/19.