3-Hydroxyquinoxaline-2-carboxylic acid

Base Information

• Chemical Name: 3-Hydroxyquinoxaline-2-carboxylic acid
• CAS No.: 1204-75-7
• Molecular Formula: C9H6 N2 O3
• Molecular Weight: 190.158
• Hs Code.: 29339900
• European Community (EC) Number: 214-877-4
• NSC Number: 34263
• UNII: 8Y9CU8XT6P
• DSSTox Substance ID: DTXSID60152852
• Nikkaji Number: J145.215K
• Mol file: 1204-75-7.mol

Synonyms:3-hydroxy-2-quinoxalinecarboxylic acid

Chemical Property of 3-Hydroxyquinoxaline-2-carboxylic acid

Chemical Property:

• Appearance/Colour: green-yellow powder and chunks
• Melting Point: 267-268 °C(lit.)
• Refractive Index: 1.5570 (estimate)
• Boiling Point: 432.4 °C at 760 mmHg
• Flash Point: 215.3 °C
• PSA: 83.31000
• Density: 1.56 g/cm³
• LogP: 1.03360
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 190.03784206
• Heavy Atom Count: 14
• Complexity: 311

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4-Dihydro-3-oxo-2-quinoxalinecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Rings
• Canonical SMILES: C1=CC=C2C(=C1)NC(=O)C(=N2)C(=O)O
• Uses: 3-Hydroxy-2-quinoxalinecarboxylic acid was used to study the sorption of ionizable organic compounds to an estuarine sediment. It was used in the preparation of Zinc(II)-quinoxaline complexes which was characterized by X-ray crystallography and fluorescence spectroscopy.

Technology Process of 3-Hydroxyquinoxaline-2-carboxylic acid

There total 18 articles about 3-Hydroxyquinoxaline-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 3-oxo-4H-quinoxaline-2-carboxylate (36818-07-2) → 3,4-Dihydro-3-oxo-2-quinoxalinecarboxylic acid (1204-75-7)

Guidance literature:

With sodium hydroxide; potassium permanganate; In water; at 100 - 120 ℃;

DOI:10.1002/hlca.19940770610

Reference yield: 68.0%

1,5-Dihydro-2H-1,5-benzodiazepin-2,3,4-trione hydrate (81225-99-2) → 3-hydroxyquinoxaline-2-carboxylic acid (1204-75-7)

Guidance literature:

With hydrogenchloride; for 0.25h; Heating;

Reference yield: 59.0%

C11H10N6O2 (110307-62-5) → 3-hydroxyquinoxaline-2-carboxylic acid (1204-75-7)

Guidance literature:

With sodium hydroxide; for 0.0833333h; Heating;

upstream raw materials:

acetonedicarboxylic acid

o-phenylenediamine hydrochloride

3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid methylamide

ethyl 3-oxo-4H-quinoxaline-2-carboxylate

Downstream raw materials:

C₂₅H₂₁ClN₄O₃

2-hydroxyquinoxaline-3-carbonyl chloride

quinoxaline-2,3-dione

3-amino-N-((2-chloro-6-methylphenyl)methyl)-2-quinoxalinecarboxamide

Refernces

• 1、 Sanna, Paolo,Carta, Antonio,Loriga, Mario,Zanetti, Stefania,Sechi, Leonardo. "Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin -3 ones for evaluation of antimicrobial and anticancer activity". . p. 455 - 461. Retrieved 2007/10/03.
• 2、 Lippmann, Eberhard,Steiner, Doris,Shilow, Wolodja. "Reaktionen mit 3-Chlor-chinoxalin-2-carbaldehyd". . p. 251 - 252. Retrieved 2007/10/02.