1,3-Propanediol, 2-ethyl-, monoacetate

Base Information

• Chemical Name: 1,3-Propanediol, 2-ethyl-, monoacetate
• CAS No.: 117935-51-0
• Molecular Formula: C7H14O3
• Molecular Weight: 146.186
• Mol file: 117935-51-0.mol

Synonyms:

Chemical Property of 1,3-Propanediol, 2-ethyl-, monoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Propanediol, 2-ethyl-, monoacetate

There total 1 articles about 1,3-Propanediol, 2-ethyl-, monoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-di-O-acetyl-2-ethyl-1,3-propanediol (161449-31-6) → 2-ethyl-1,3-propandiol (2612-29-5) + (R)-1-O-acetyl-2-ethyl-1,3-propanediol (117935-51-0) + (2S)-2-(hydroxymethyl)butyl acetate

Guidance literature:

With lipase from Pseudomonas Cepacia; sodium chloride; calcium chloride; sodium hydroxide; BSA; In water; at 37 ℃; pH=7.5; optical yield given as %ee; Enzymatic reaction;

DOI:10.1002/ejoc.201000539

Reference yield: 60.0%

(R)-1-O-acetyl-2-ethyl-1,3-propanediol (117935-51-0) + p-toluenesulfonyl chloride (98-59-9) → (2S)-3-(p-tolylsulfonyloxy)-2-ethylprop-1-yl acetate (161449-61-2)

Guidance literature:

With dmap; In dichloromethane; for 48h; Ambient temperature;

Reference yield:

(R)-1-O-acetyl-2-ethyl-1,3-propanediol (117935-51-0) → (2S)-2-methyl-1-butanol (1565-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 4-N,N-dimethylaminopyridine / CH₂Cl₂ / 48 h / Ambient temperature

2: 90 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; In diethyl ether; dichloromethane;

upstream raw materials:

1,3-di-O-acetyl-2-ethyl-1,3-propanediol

Downstream raw materials:

(2S)-3-(p-tolylsulfonyloxy)-2-ethylprop-1-yl acetate

(5R,6S)-(+)-6-(tert-butyldiphenylsilyloxymethyl)-5-ethylpiperidin-2-one

methyl (2S,3R)-(-)-2-(tert-butyldiphenylsilyloxymethyl)-3-ethyl-6-oxopiperidine-1-carboxylate

dimethyl (5R,6S)-(-)-6-(tert-butyldiphenylsilyloxymethyl)-5-ethyl-5,6-dihydro-4H-pyridine-1,2-dicarboxylate

Refernces