2'-TBDMS-Ac-rC

Base Information

• Chemical Name: 2'-TBDMS-Ac-rC
• CAS No.: 119794-51-3
• Molecular Formula: C17H29N3O6Si
• Molecular Weight: 399.51400
• Mol file: 119794-51-3.mol

Synonyms:2'-TBDMS-Ac-rC;

Chemical Property of 2'-TBDMS-Ac-rC

Chemical Property:

• PSA: 122.91000
• LogP: 0.91570

Purity/Quality:

98%,99%, ^*data from raw suppliers

2'-TBDMS-Ac-rC 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-TBDMS-Ac-rC

There total 3 articles about 2'-TBDMS-Ac-rC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

tert-butyldimethylsilyl chloride (18162-48-6) + N-acetylcytidine (3768-18-1) → N4-acetyl-5'-O-(tert-butyldimethylsilyl)cytidine (119794-51-3)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 20h;

DOI:10.1021/jo00270a036

Reference yield: 64.0%

N-(tert-butyldimethylsilyl)imidazole (54925-64-3) + N-acetylcytidine (3768-18-1) → N4-acetyl-5'-O-(tert-butyldimethylsilyl)cytidine (119794-51-3)

Guidance literature:

In formic acid; Ambient temperature;

DOI:10.1021/jo00038a042

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N4-acetyl-5'-O-(tert-butyldimethylsilyl)cytidine (119794-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 1 h / Ambient temperature

2: 64 percent / formic acid / Ambient temperature

In formic acid; N,N-dimethyl-formamide;

DOI:10.1021/jo00038a042

upstream raw materials:

tert-butyldimethylsilyl chloride

N-acetylcytidine

N-(tert-butyldimethylsilyl)imidazole

Refernces

• 1、 Manchand,Belica,Holman,Huang,Maehr,Tam,Yang. "Syntheses of the anti-AIDS drug 2',3'-dideoxycytidine from cytidine". . p. 3473 - 3478. Retrieved 2007/10/02.