Benzonitrile, 4-(2,4-dimethyl-5-thiazolyl)-

Base Information

• Chemical Name: Benzonitrile, 4-(2,4-dimethyl-5-thiazolyl)-
• CAS No.: 122957-56-6
• Molecular Formula: C12H10N2S
• Molecular Weight: 214.291
• Mol file: 122957-56-6.mol

Synonyms:

Chemical Property of Benzonitrile, 4-(2,4-dimethyl-5-thiazolyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzonitrile, 4-(2,4-dimethyl-5-thiazolyl)-

There total 4 articles about Benzonitrile, 4-(2,4-dimethyl-5-thiazolyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,4-dimethylthiazole (541-58-2) + 4-bromobenzenecarbonitrile (623-00-7) → 4-(2,4-dimethylthiazol-5-yl)benzonitrile (122957-56-6)

Guidance literature:

With C₃₄H₄₈Cl₂N₂Pd; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 100 ℃; for 8h;

DOI:10.1039/c7ob00856b

Reference yield: 64.0%

thioacetamide (62-55-5) + 1-bromo-1-(4-cyanophenyl)-2-oxopropane (122957-58-8) → 4-(2,4-dimethylthiazol-5-yl)benzonitrile (122957-56-6)

Guidance literature:

With pyridine; In toluene; at 100 ℃; for 1h;

DOI:10.1021/jm00095a005

Reference yield: 59.0%

2,4-dimethyl-thiazole-5-carboxylic acid (53137-27-2) + 4-bromobenzenecarbonitrile (623-00-7) → 4-(2,4-dimethylthiazol-5-yl)benzonitrile (122957-56-6)

Guidance literature:

With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 160 ℃; Inert atmosphere;

DOI:10.1039/c6ra12166g

upstream raw materials:

thioacetamide

1-bromo-1-(4-cyanophenyl)-2-oxopropane

4-(2-oxopropyl)benzonitrile

2,4-dimethylthiazole

Downstream raw materials:

4-(2-Chloro-phenyl)-2-[4-(2,4-dimethyl-thiazol-5-yl)-phenyl]-6-methyl-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

3-[4-(2,4-Dimethyl-thiazol-5-yl)-phenyl]-3-oxo-propionic acid ethyl ester

Refernces

• 1、 Chen, Fu-Min,Lu, Dong-Dong,Hu, Li-Qun,Huang, Ju,Liu, Feng-Shou. "Camphyl-based α-diimine palladium complexes: Highly efficient precatalysts for direct arylation of thiazoles in open-air". . p. 5731 - 5736. Retrieved 2017/07/22.
• 2、 Karale, Uttam B.,Kalari, Saradhi,Shivakumar, Jala,Makane, Vitthal B.,Babar, Dattatraya A.,Thakare, Ritesh P.,Babu, Bathini Nagendra,Chopra, Sidharth,Rode, Haridas B.. "Ligand-free Pd-catalysed decarboxylative arylation of imidazo[1,2-: A] pyridine-3-carboxylic acids with aryl bromides". . p. 65095 - 65104. Retrieved 2016/07/21.