2-Chloro-8-fluoroquinoline

Base Information

• Chemical Name: 2-Chloro-8-fluoroquinoline
• CAS No.: 124467-23-8
• Molecular Formula: C9H5ClFN
• Molecular Weight: 181.597
• Hs Code.: 2933499090
• Mol file: 124467-23-8.mol

Synonyms:Quinoline,2-chloro-8-fluoro;

Chemical Property of 2-Chloro-8-fluoroquinoline

Chemical Property:

• Melting Point: 82-84℃
• Boiling Point: 271.3±20.0 °C(Predicted)
• PKA: -2.73±0.50(Predicted)
• PSA: 12.89000
• Density: 1.366±0.06 g/cm3(Predicted)
• LogP: 3.02730
• Storage Temp.: Room temperature.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-8-fluoroquinoline 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-8-fluoroquinoline

There total 5 articles about 2-Chloro-8-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

8-fluoroquinolin-2(1H)-one (71738-83-5) → 2-chloro-8-fluoroquinoline (124467-23-8)

Guidance literature:

With trichlorophosphate; at 125 ℃; for 2h;

Reference yield:

2-hydroxy-8-fluoroquinoline (71738-83-5) → 2-chloro-8-fluoroquinoline (124467-23-8)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane; at 70 ℃;

Reference yield:

(2E)-N-(2-fluorophenyl)-3-phenylprop-2-enamide (1065481-24-4) → 2-chloro-8-fluoroquinoline (124467-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / chlorobenzene / 3 h / 125 °C

2: trichlorophosphate / 2 h / 125 °C

With aluminum (III) chloride; trichlorophosphate; In chlorobenzene;

upstream raw materials:

2-Chloroquinoline

8-fluoroquinolin-2(1H)-one

2-hydroxy-8-fluoroquinoline

(2E)-N-(2-fluorophenyl)-3-phenylprop-2-enamide

Downstream raw materials:

2-hydroxy-8-fluoroquinoline

(R)-1-(2-chloro-8-fluoroquinolin-3-yl)ethanol

2-((1S)-1-(8-fluoro-2-(2-(methylthio)phenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione

2-((1S)-1-(8-fluoro-2-(2-(methylsulfonyl)phenyl)-3-quinolinyl)ethyl)-1H-isoindole-1,3(2H)-dione

Refernces

• 1、 -. "TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS". Page/Page column 116. . Retrieved 2010/04/03.
• 2、 Chambers, Richard D.,Holling, Darren,Sandford, Graham,Batsanov, Andrei S.,Howard, Judith A.K.. "Elemental fluorine Part 15. Selective direct fluorination of quinoline derivatives". . p. 661 - 671. Retrieved 2007/10/03.