Grifolic acid

Base Information

• Chemical Name: Grifolic acid
• CAS No.: 80557-12-6
• Molecular Formula: C23H32O4
• Molecular Weight: 372.505
• Mol file: 80557-12-6.mol

Synonyms:

Chemical Property of Grifolic acid

Chemical Property:

• Melting Point: 93-94 °C(Solv: hexane (110-54-3))
• Boiling Point: 557.1±50.0 °C(Predicted)
• PKA: 3.22±0.25(Predicted)
• PSA: 77.76000
• Density: 1.086±0.06 g/cm3(Predicted)
• LogP: 6.06610
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Grifolic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Grifolic Acid is a selective partial GPR120 agonist. Grifolic Acid induces ERK and [Ca2+]i responses in cells expressing GPR120, but has no effects on those expressing GPR40.

Technology Process of Grifolic acid

There total 1 articles about Grifolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

7-hydroxy-2,2,5-trimethyl-8-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)-4H-benzo[d][1,3]dioxin-4-one → Grifolic acid (80557-12-6)

Guidance literature:

With potassium tert-butylate; water; In diethyl ether; at 25 ℃; for 72h;

DOI:10.1016/j.tetlet.2017.05.096

Reference yield:

Grifolic acid (80557-12-6) → grifolin (6903-07-7)

Guidance literature:

With methanol; sodium hydroxide; at 60 ℃; for 3h;

Reference yield:

Grifolic acid (80557-12-6) → 2-[3-((E)-4,8-Dimethyl-nona-3,7-dienyl)-3-methyl-oxiranylmethyl]-5-methyl-benzene-1,3-diol

Guidance literature:

Multi-step reaction with 2 steps

1: 1percent NaOH-MeOH / 3 h / 60 °C

2: 219 mg / m-chloroperbenzoic acid / CHCl₃ / 3 h / -30 °C

With methanol; sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In chloroform;

Downstream raw materials:

grifolin

(+)-daurichromenic acid

Refernces