Carbamic chloride, (4-fluorophenyl)phenyl-

Base Information

• Chemical Name: Carbamic chloride, (4-fluorophenyl)phenyl-
• CAS No.: 13020-93-4
• Molecular Formula: C13H9ClFNO
• Molecular Weight: 249.672
• Mol file: 13020-93-4.mol

Synonyms:

Chemical Property of Carbamic chloride, (4-fluorophenyl)phenyl-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic chloride, (4-fluorophenyl)phenyl-

There total 6 articles about Carbamic chloride, (4-fluorophenyl)phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

phosgene (75-44-5) + N-(4-fluorophenyl)aniline (330-83-6) → N-(4-fluorophenyl)-N-phenylcarbamoyl chloride (13020-93-4)

Guidance literature:

With pyridine; In chloroform;

DOI:10.1021/ja00324a038

Reference yield:

4'-fluoroacetanilide (351-83-7) → N-(4-fluorophenyl)-N-phenylcarbamoyl chloride (13020-93-4)

Guidance literature:

Multi-step reaction with 3 steps

1: CuCl; K₂CO₃ / xylene

2: aq. NaOH / ethanol

3: pyridine / CH₂Cl₂

With pyridine; sodium hydroxide; potassium carbonate; copper(l) chloride; In ethanol; dichloromethane; xylene;

DOI:10.1016/j.bmcl.2006.06.033

Reference yield:

N-(4-fluorophenyl)-N-phenylacetamide (13024-31-2) → N-(4-fluorophenyl)-N-phenylcarbamoyl chloride (13020-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol

2: pyridine / CH₂Cl₂

With pyridine; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.06.033

upstream raw materials:

phosgene

N-(4-fluorophenyl)aniline

bis(trichloromethyl) carbonate

bromobenzene

Downstream raw materials:

(2R)-2-[(N-4-fluorophenyl-N-phenylcarbamoyloxy)methyl]-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydro-naphthalene

Refernces

• 1、 Takamura, Fujiko,Tanaka, Akira,Takasugi, Hisashi,Taniguchi, Kiyoshi,Nishio, Mie,Seki, Jiro,Hattori, Kouji. "Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5". . p. 4475 - 4478. Retrieved 2007/10/03.