Urea, N-(2-iodophenyl)-N'-phenyl-

Base Information

• Chemical Name: Urea, N-(2-iodophenyl)-N'-phenyl-
• CAS No.: 13114-94-8
• Molecular Formula: C13H11IN2O
• Molecular Weight: 338.148
• Mol file: 13114-94-8.mol

Synonyms:

Chemical Property of Urea, N-(2-iodophenyl)-N'-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Urea, N-(2-iodophenyl)-N'-phenyl-

There total 7 articles about Urea, N-(2-iodophenyl)-N'-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-iodophenylamine (615-43-0) + phenyl isocyanate (103-71-9) → 1-(2-iodophenyl)-3-phenylurea (13114-94-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.02.108

Reference yield: 91.0%

(1H-benzo[d][1,2,3]triazol-1-yl)(2-iodophenyl)methanone (332021-26-8) + aniline (62-53-3) → 1-(2-iodophenyl)-3-phenylurea (13114-94-8)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 110 ℃; Sealed tube;

DOI:10.1055/a-1399-3823

Reference yield: 86.0%

1-benzoyl-1H-benzotriazole (4231-62-3) + 2-iodophenylamine (615-43-0) → 1-(2-iodophenyl)-3-phenylurea (13114-94-8)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 110 ℃; Sealed tube;

DOI:10.1055/a-1399-3823

upstream raw materials:

2-iodophenylamine

phenyl isocyanate

2-Iodobenzoic acid

aniline

Downstream raw materials:

1-benzyl-1-(2-iodophenyl)-3-phenylurea

3-phenyl-2,4-(1H,3H)-quinazolinedione

2-anilinoquinazolin-4(3H)-one

1-(2-iodophenyl)-1,3-dimethyl-3-phenylurea

Refernces

• 1、 Costil, Romain,Dale, Harvey J. A.,Fey, Natalie,Whitcombe, George,Matlock, Johnathan V.,Clayden, Jonathan. "Heavily Substituted Atropisomeric Diarylamines by Unactivated Smiles Rearrangement of N-Aryl Anthranilamides". supporting information. p. 12533 - 12537. Retrieved 2017/09/13.
• 2、 Koshti, Vijay S.,Thorat, Shridhar H.,Gote, Ravindra P.,Chikkali, Samir H.,Gonnade, Rajesh G.. "The impact of modular substitution on crystal packing: The tale of two ureas". . p. 7078 - 7094. Retrieved 2016/10/03.