2-Naphthalenemethanol, a-ethyl-

Base Information

• Chemical Name: 2-Naphthalenemethanol, a-ethyl-
• CAS No.: 132154-59-7
• Molecular Formula: C13H14O
• Molecular Weight: 186.254
• Mol file: 132154-59-7.mol

Synonyms:

Chemical Property of 2-Naphthalenemethanol, a-ethyl-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Naphthalenemethanol, a-ethyl-

There total 16 articles about 2-Naphthalenemethanol, a-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

diethylzinc (557-20-0) + β-naphthaldehyde (66-99-9) + phenylacetylene (536-74-3) → 1-(naphthalen-2-yl)propan-1-ol (132154-59-7) + (R)-(-)-1-(2-naphthyl)-3-phenylprop-2-yn-1-ol

Guidance literature:

diethylzinc; phenylacetylene; With (S)-2-(p-toluenesulfonylamino)-1,1-diethyl-3-phenyl-1-propanol; titanium(IV) isopropylate; In toluene; at 20 ℃; for 0.5h;

With methanol; In toluene; at 20 ℃; for 0.5h;

β-naphthaldehyde; In toluene; at 20 ℃; for 18h;

DOI:10.1002/adsc.200505453

Reference yield: 50.0%

2,2-diphenylacetic acid (117-34-0) + 1-(naphthalen-2-yl)propan-1-ol (132154-59-7) → (R)-1-(2-naphthyl)propyl diphenylacetate (1345412-62-5) + (S)-1-(2-naphthyl)propan-1-ol (112576-12-2,132154-59-7,87241-23-4)

Guidance literature:

With (R)-9-methyl-2-phenyl-9-hydro-2-imidazolino[1,2-a]benzimidazole; 2,2-dimethylpropanoic anhydride; In diethyl ether; at 20 ℃; for 12h; optical yield given as %ee; Resolution of racemate;

DOI:10.1039/c1ob05736g

Reference yield: 3.0%

diethylzinc (557-20-0) + β-naphthaldehyde (66-99-9) → 2-Naphthalenemethanol (1592-38-7) + (R)-1-(2-naphthyl)propanol (87241-23-4,132154-59-7,112576-12-2) + (S)-1-(2-naphthyl)propan-1-ol (112576-12-2,132154-59-7,87241-23-4)

Guidance literature:

With (S)-1²-(hydroxymethyl)-1⁴-methyl-1(5,8)-quinolina-4(1,4)-benzenacyclohexaphane; In toluene; at 20 ℃; for 14h; Further Variations:; Reagents; Temperatures; time; Product distribution;

DOI:10.1055/s-2002-25350

upstream raw materials:

diethylzinc

β-naphthaldehyde

phenylboronic acid

phenylacetylene

Downstream raw materials:

2-(prop-1-en-1-yl)naphthalene

(R)-1-(2-naphthyl)propyl diphenylacetate

(S)-1-(2-naphthyl)propan-1-ol

1-(naphthalen-2-yl)propyl 2-(benzoylthio)acetate

Refernces

• 1、 Slagbrand, Tove,Lundberg, Helena,Adolfsson, Hans. "Ruthenium-catalyzed tandem-isomerization/asymmetric transfer hydrogenation of allylic alcohols". supporting information. p. 16102 - 16106. Retrieved 2015/01/09.
• 2、 Nakata, Kenya,Shiina, Isamu. "(R)-(+)-N-methylbenzoguanidine ((R)-NMBG) catalyzed kinetic resolution of racemic secondary benzylic alcohols with free carboxylic acids by asymmetric esterification". supporting information; experimental part. p. 7092 - 7096. Retrieved 2011/11/04.