Conioidine A

Base Information

• Chemical Name: Conioidine A
• CAS No.: 154887-98-6
• Molecular Formula: C₂₂H₃₉NO₃
• Molecular Weight: 365.557
• ChEMBL ID: CHEMBL518130
• Mol file: 154887-98-6.mol

Synonyms:conioidine A

Chemical Property of Conioidine A

Chemical Property:

• Vapor Pressure: 2.03E-09mmHg at 25°C
• Boiling Point: 481.2°Cat760mmHg
• PKA: -0.84±0.40(Predicted)
• Flash Point: 244.8°C
• PSA: 46.61000
• Density: 0.969g/cm³
• LogP: 5.34400
• XLogP3: 6.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 13
• Exact Mass: 365.29299411
• Heavy Atom Count: 26
• Complexity: 458

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCC(=O)N1CCCC1CC(C)OC(=O)C(=CC)C
• Isomeric SMILES: CCCCCCCCCC(=O)N1CCCC1CC(C)OC(=O)/C(=C/C)/C

Technology Process of Conioidine A

There total 32 articles about Conioidine A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α,β-dimethyl acryloyl chloride (49651-33-4) + C17H33NO2 → (4S,6S)-conioidine A (154887-98-6)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.jnatprod.0c00871

Reference yield:

α,β-dimethyl acryloyl chloride (49651-33-4) + C17H33NO2 → (4S,6R)-conioidine A (154887-98-6)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.jnatprod.0c00871

Reference yield:

α,β-dimethyl acryloyl chloride (49651-33-4) + C17H33NO2 → (4R,6R)-conioidine A (154887-98-6)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.jnatprod.0c00871

upstream raw materials:

N-(tert-butoxycarbonyl)-L-prolinol

(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate

(S)-2-cyanomethylpyrrolidine-1-carboxylic acid tert-butyl ester

(S)-tert-butyl 2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate

Refernces