2,3,5,6-TETRAFLUORO-4-METHYLBENZOIC ACID

Base Information

• Chemical Name: 2,3,5,6-TETRAFLUORO-4-METHYLBENZOIC ACID
• CAS No.: 652-32-4
• Molecular Formula: C8H4F4O2
• Molecular Weight: 208.112
• Hs Code.: 29163990
• Mol file: 652-32-4.mol

Synonyms:p-Toluic acid,2,3,5,6-tetrafluoro- (7CI,8CI);2,3,5,6-Tetrafluoro-4-methylbenzoic acid;2,3,5,6-Tetrafluoro-p-toluic acid;NSC 168718;

Chemical Property of 2,3,5,6-TETRAFLUORO-4-METHYLBENZOIC ACID

Chemical Property:

• Appearance/Colour: white to almost white crystals
• Vapor Pressure: 0.00822mmHg at 25°C
• Melting Point: 173-175 °C
• Boiling Point: 255.8 °C at 760 mmHg
• PKA: 1.83±0.10(Predicted)
• Flash Point: 108.5 °C
• PSA: 37.30000
• Density: 1.54 g/cm³
• LogP: 2.24960
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3,5,6-Tetrafluoro-4-methylbenzoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,C
• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3,5,6-Tetrafluoro-p-toluic acid may be used in chemical synthesis.

Technology Process of 2,3,5,6-TETRAFLUORO-4-METHYLBENZOIC ACID

There total 7 articles about 2,3,5,6-TETRAFLUORO-4-METHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 2,3,5,6-tetrafluorotoluene (5230-78-4) → 2,3,5,6-tetrafluoro-4-methylbenzoic acid (652-32-4)

Guidance literature:

Multistep reaction; (i) nBuLi, (ii) /BRN= 1900390/, (iii) aq. HCl;

DOI:10.1021/jo01341a023

Reference yield:

2,3,5,6-tetrafluorotoluene (5230-78-4) → 2,3,5,6-tetrafluoro-4-methylbenzoic acid (652-32-4)

Guidance literature:

With hydrogenchloride; n-butyllithium; In diethyl ether; hexane;

Reference yield:

n-butyllithium (109-72-8,29786-93-4) + 2,3,5,6-tetrafluorotoluene (5230-78-4) → 2,3,5,6-tetrafluoro-4-methylbenzoic acid (652-32-4)

Guidance literature:

In Dimethoxymethane; hexane;

upstream raw materials:

carbon dioxide

2,3,5,6-tetrafluorotoluene

2,3,4,5,6-pentafluorotoluene

perfluorotoluene

Downstream raw materials:

2,3,5,6-tetrafluoro-4-toluamide

4-methoxycarbonyl-2,3,5,6-tetrafluorotoluene

C₈H₃ClF₄O

potassium 2,3,5,6-tetrafluoro-4-methylbenzoate

Refernces

• 1、 -. "INHIBITORS OF STEAROYL-COA DESATURASE". . . Retrieved 2009/06/27.
• 2、 -. "Halogenated esters". . . Retrieved 2008/06/13.