2-Amino-6-chloro-4-pyrimidinol

Base Information

• Chemical Name: 2-Amino-6-chloro-4-pyrimidinol
• CAS No.: 1194-21-4
• Molecular Formula: C4H4ClN3O
• Molecular Weight: 145.548
• Hs Code.: 29335990
• Mol file: 1194-21-4.mol

Synonyms:4(3H)-Pyrimidinone,2-amino-6-chloro- (7CI);4-Pyrimidinol, 2-amino-6-chloro- (8CI);2-Amino-4-chloro-6-hydroxypyrimidine;2-Amino-4-chloropyrimidine-6-one;2-Amino-4-hydroxy-6-chloropyrimidine;2-Amino-6-chloro-3H-pyrimidin-4-one;2-Amino-6-chloro-4(1H)-pyrimidinone;2-Amino-6-chloro-4(3H)-pyrimidinone;2-Amino-6-chloro-4-pyrimidinol;2-Amino-6-chloro-4-pyrimidinone;6-Chloroisocytosine;NSC 35655;

Chemical Property of 2-Amino-6-chloro-4-pyrimidinol

Chemical Property:

• Vapor Pressure: 0.00676mmHg at 25°C
• Melting Point: 252 °C (dec.)(lit.)
• Refractive Index: 1.717
• Boiling Point: 259.1 °C at 760 mmHg
• PKA: 7.49±0.50(Predicted)
• Flash Point: 110.5 °C
• PSA: 72.03000
• Density: 1.79 g/cm³
• LogP: 0.99900
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Sparingly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-?Amino-?6-?chloro-?4-?pyrimidinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-20/21/22
• Safety Statements: 26-36-36/37-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-?Amino-?6-?chloro-?4-?pyrimidinol is used to prepare O- and N-phosphonomethoxyalkyl pyrimidines with antiviral activities. It is also used to synthesize (±)?-?9-?[[(Z)?-?2-?(hydroxymethyl)?cyclopropyl]?methyl]?guanine with antiherpetic activities.

Technology Process of 2-Amino-6-chloro-4-pyrimidinol

There total 8 articles about 2-Amino-6-chloro-4-pyrimidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,6-dichloropyrimidine (1193-21-1) → 6-chloroisocytosine (1194-21-4)

Guidance literature:

With acetic acid; In sodium hydroxide;

Reference yield: 96.0%

2-Amino-4,6-dichloropyrimidine (56-05-3) → 6-chloroisocytosine (1194-21-4)

Guidance literature:

With sodium hydroxide; for 1h; Heating;

DOI:10.1002/1521-3765(20020104)8:1<293::AID-CHEM293>3.0.CO;2-L

Reference yield: 88.0%

2-Amino-4,6-dichloropyrimidine (56-05-3) → 2-amino-6-chloro-4-pyrimidinol (1194-21-4)

Guidance literature:

With sodium hydroxide; for 2h; Heating;

DOI:10.1016/j.tet.2007.07.100

upstream raw materials:

2-Amino-4,6-dichloropyrimidine

2-amino-4-chloro-6-methoxypyrimidine

2-amino-6-hydroxy-pyrimidin-4(3H)-one

4,6-dichloropyrimidine

Downstream raw materials:

2-amino-6-(n-propylamino)pyrimidin-4(3H)-one

2-amino-6-(3-phenylpropyl)aminopyrimidin-4(3H)-one

2-Amino-6-cyclohexylamino-3H-pyrimidin-4-one

2-Amino-4,6-di(p-toluidino)pyrimidine

Refernces

• 1、 Savall, Brad M.,Chavez, Frank,Tays, Kevin,Dunford, Paul J.,Cowden, Jeffery M.,Hack, Michael D.,Wolin, Ronald L.,Thurmond, Robin L.,Edwards, James P.. "Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H 4 receptor antagonists". . p. 2429 - 2439. Retrieved 2014/04/17.
• 2、 -. "BIOACTIVE COMPOUNDS FOR TREATMENT OF CANCER AND NEURODEGENERATIVE DISEASES". Page/Page column 93. . Retrieved 2009/12/23.