1-(3-AMINOPROPYL)-2-PIPECOLINE

Base Information

• Chemical Name: 1-(3-AMINOPROPYL)-2-PIPECOLINE
• CAS No.: 25560-00-3
• Molecular Formula: C9H20N2
• Molecular Weight: 156.271
• Hs Code.: 2933399090
• European Community (EC) Number: 247-102-3
• DSSTox Substance ID: DTXSID701306410
• Nikkaji Number: J149.314K
• Mol file: 25560-00-3.mol

Synonyms:2-Pipecoline,1-(3-aminopropyl)- (8CI);1-(3-Aminopropyl)-2-methylhexahydropyridine;1-(3-Aminopropyl)-2-methylpiperidine;1-(3-Aminopropyl)-2-pipecoline;2-Methyl-1-piperidinepropanamine;3-(2-Methyl-1-piperidinyl)-1-propanamine;3-(2-Methylpiperidin-1-yl)propylamine;3-(2-Methylpiperidino)propylamine;N-(3-Aminopropyl)-2-methylpiperidine;

Chemical Property of 1-(3-AMINOPROPYL)-2-PIPECOLINE

Chemical Property:

• Vapor Pressure: 0.191mmHg at 25°C
• Refractive Index: n20/D 1.4765(lit.)
• Boiling Point: 210.6 °C at 760 mmHg
• PKA: 10.44±0.10(Predicted)
• Flash Point: 88.3 °C
• PSA: 29.26000
• Density: 0.891 g/cm³
• LogP: 1.84780
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 156.162648646
• Heavy Atom Count: 11
• Complexity: 104

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3-Aminopropyl)-2-methylpiperidine >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCCCN1CCCN
• Uses: Reactant for synthesis of: Photostable near-infrared cyanine dyes Quinazolindione derivatives as 5-HT3A receptor antagonists Melanocortin-4 receptor antagonists Brain penetrant aminoalkyl benzoimidazoles Selective nitric oxide formation inhibitors

Technology Process of 1-(3-AMINOPROPYL)-2-PIPECOLINE

There total 2 articles about 1-(3-AMINOPROPYL)-2-PIPECOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-(2-Methyl-piperidino)-propylamin (25560-00-3)

Guidance literature:

With methanol; ammonia; nickel; at 100 ℃; under 58840.6 Torr; Hydrogenation;

DOI:10.1021/ja01179a507

Reference yield:

→ 3-(2-Methyl-piperidino)-propylamin (25560-00-3)

Guidance literature:

Reference yield: 75.0%

3-(2-Methyl-piperidino)-propylamin (25560-00-3) + 4-Phenylbutyric acid (1821-12-1) → N?(3?(2?methylpiperidin?1?yl)propyl)?4?phenylbutanamide

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In ethyl acetate; at 20 ℃; for 12h;

DOI:10.1007/s43440-021-00226-2

Downstream raw materials:

(5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-[3-(2-methyl-piperidin-1-yl)-propyl]-amine

4-(2-Fluoro-phenyl)-1,3-dimethyl-5-[3-(2-methyl-piperidin-1-yl)-propylamino]-1,7-dihydro-pyrazolo[3,4-b]pyridin-6-one

N-[4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl]-2-{[3-(2-methyl-1-piperidinyl)propyl]amino}acetamide

4-(2-Fluoro-phenyl)-1,3,7-trimethyl-5-[3-(2-methyl-piperidin-1-yl)-propylamino]-1,7-dihydro-pyrazolo[3,4-b]pyridin-6-one

Refernces

• 1、 -. "2-aminopyridine derivatives and combinatorial libraries thereof". . . Retrieved 2008/06/13.