Pentanoic acid, 2-methyl-3-oxo-, 1-ethylpropyl ester, (S)-

Base Information

• Chemical Name: Pentanoic acid, 2-methyl-3-oxo-, 1-ethylpropyl ester, (S)-
• CAS No.: 137708-19-1
• Molecular Formula: C11H20O3
• Mol file: 137708-19-1.mol

Synonyms:

Chemical Property of Pentanoic acid, 2-methyl-3-oxo-, 1-ethylpropyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanoic acid, 2-methyl-3-oxo-, 1-ethylpropyl ester, (S)-

There total 3 articles about Pentanoic acid, 2-methyl-3-oxo-, 1-ethylpropyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-pentyl α-methyldiazoacetate (1401455-74-0) + propionaldehyde (123-38-6) → (S)-pentan-3-yl 2-methyl-3-oxopentanoate (137708-19-1) + ethyl-2-formyl-2-methylbutanoate (188026-75-7)

Guidance literature:

With C₃H₄F₅NO₄S₂*C₃₁H₃₂BNO; In toluene; at -95 ℃; for 1h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201204350

Reference yield:

C10H18O3 (1384266-02-7) → (S)-pentan-3-yl 2-methyl-3-oxopentanoate (137708-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 0 - 20 °C / Inert atmosphere

2: C₃H₄F₅NO₄S₂*C₃₁H₃₂BNO / toluene / 1 h / -95 °C / Inert atmosphere

With 4-acetamidobenzenesulfonyl azide; C₃H₄F₅NO₄S₂*C₃₁H₃₂BNO; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; acetonitrile; 2: Roskamp reaction;

DOI:10.1002/anie.201204350

Reference yield:

pentan-3-yl 3-oxobutanoate (13562-81-7) → (S)-pentan-3-yl 2-methyl-3-oxopentanoate (137708-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Reflux; Inert atmosphere

2: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 0 - 20 °C / Inert atmosphere

3: C₃H₄F₅NO₄S₂*C₃₁H₃₂BNO / toluene / 1 h / -95 °C / Inert atmosphere

With 4-acetamidobenzenesulfonyl azide; C₃H₄F₅NO₄S₂*C₃₁H₃₂BNO; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; toluene; acetonitrile; mineral oil; 3: Roskamp reaction;

DOI:10.1002/anie.201204350

upstream raw materials:

C₁₀H₁₈O₃

3-pentyl α-methyldiazoacetate

propionaldehyde

pentan-3-yl 3-oxobutanoate

Refernces