[4-(4-Chlorophenyl)cyclohexyl]methanol

Base Information

• Chemical Name: [4-(4-Chlorophenyl)cyclohexyl]methanol
• CAS No.: 137736-28-8
• Molecular Formula: C13H17ClO
• Molecular Weight: 224.73
• European Community (EC) Number: 688-029-0
• Mol file: 137736-28-8.mol

Synonyms:[4-(4-chlorophenyl)cyclohexyl]methanol;137736-28-8;[trans-4-(4-Chlorophenyl)cyclohexyl]methanol;[trans-4-(4-Chlorophenyl)cyclohexyl]Methanol, 97per cent;SCHEMBL2166886;SCHEMBL9264511;INSWJXJRICZMOG-UHFFFAOYSA-N;INSWJXJRICZMOG-XYPYZODXSA-N;MFCD18803466;AKOS025396879;CS-0132484;trans-4-(4-Chlorophenyl)cyclohexyl)methanol;E81619;trans-(4-(4-chlorophenyl)cyclohexyl) methanol

Chemical Property of [4-(4-Chlorophenyl)cyclohexyl]methanol

Chemical Property:

• Melting Point: 56-60℃
• PSA: 20.23000
• LogP: 3.60610
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 224.0967929
• Heavy Atom Count: 15
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

[trans-4-(4-Chlorophenyl)cyclohexyl]methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CCC1CO)C2=CC=C(C=C2)Cl

Technology Process of [4-(4-Chlorophenyl)cyclohexyl]methanol

There total 1 articles about [4-(4-Chlorophenyl)cyclohexyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid (95233-37-7,49708-81-8,1346600-43-8) → [trans-4-(4-chlorophenyl)cyclohexyl]methanol (137736-28-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 55 - 60 ℃; for 4h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

Reference yield: 92.9%

[trans-4-(4-chlorophenyl)cyclohexyl]methanol (137736-28-8) + 4-ethylphenylboronic acid (63139-21-9) → 4-{4'-ethyl-[1,1'-biphenyl]-4-yl}cyclohexyl methanol

Guidance literature:

With palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 4h; Inert atmosphere;

Reference yield: 89.3%

[trans-4-(4-chlorophenyl)cyclohexyl]methanol (137736-28-8) + 4-methylphenylboronic acid (5720-05-8) → 4-{4'-methyl-[1,1'-biphenyl]-4-yl}cyclohexyl methanol

Guidance literature:

With palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 4h; Inert atmosphere;

upstream raw materials:

(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid

Downstream raw materials:

1-[trans-4-(bromomethyl)cyclohexyl]-4-chlorobenzene

Refernces

• 1、 -. "FARNESOID X RECEPTOR AGONISTS AND USES THEREOF". Paragraph 00405. . Retrieved 2017/04/11.