Benzoic acid, 2-acetyl-1,2-dimethylhydrazide

Base Information

• Chemical Name: Benzoic acid, 2-acetyl-1,2-dimethylhydrazide
• CAS No.: 138211-83-3
• Molecular Formula: C11H14N2O2
• Molecular Weight: 206.244
• Mol file: 138211-83-3.mol

Synonyms:

Chemical Property of Benzoic acid, 2-acetyl-1,2-dimethylhydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 2-acetyl-1,2-dimethylhydrazide

There total 4 articles about Benzoic acid, 2-acetyl-1,2-dimethylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Benzoesaeure-1,2-dimethylhydrazid (80791-41-9) + acetyl chloride (75-36-5) → N'-acetyl-N,N'-dimethylbenzohydrazide (138211-83-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2.75h;

DOI:10.1039/d0cc00943a

Reference yield: 71.0%

1-acetyl-2-benzoylhydrazine (14331-27-2) + Methyl benzenesulfonate (80-18-2) → N'-acetyl-N,N'-dimethylbenzohydrazide (138211-83-3)

Guidance literature:

With sodium hydroxide; In water; at 90 ℃; for 0.5h;

DOI:10.1055/s-1991-26588

Reference yield:

benzoyl chloride (98-88-4) → N'-acetyl-N,N'-dimethylbenzohydrazide (138211-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

1.2: 0.75 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.75 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1039/d0cc00943a

upstream raw materials:

1-acetyl-2-benzoylhydrazine

Methyl benzenesulfonate

benzoyl chloride

Benzoesaeure-1,2-dimethylhydrazid

Downstream raw materials:

1,2-dimethyl-5-phenyl-1,2-dihydro-pyrazol-3-one

Refernces

• 1、 Magedov,Smushkevich. "A new method for synthesis of 1H-pyrazol-3(2H)-ones". . p. 845 - 848. Retrieved 2007/10/02.