Propanedioic acid, methoxy-, methyl phenylmethyl ester, (S)-

Base Information

• Chemical Name: Propanedioic acid, methoxy-, methyl phenylmethyl ester, (S)-
• CAS No.: 138434-85-2
• Molecular Formula: C12H14O5
• Molecular Weight: 238.24
• Mol file: 138434-85-2.mol

Synonyms:

Chemical Property of Propanedioic acid, methoxy-, methyl phenylmethyl ester, (S)-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid, methoxy-, methyl phenylmethyl ester, (S)-

There total 6 articles about Propanedioic acid, methoxy-, methyl phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

dimethyl methoxymalonate (5018-30-4) + benzyl alcohol (100-51-6,185532-71-2) → (S)-(-)-benzyl,methyl 2-methoxymalonate (138434-85-2)

Guidance literature:

In hexane; at 40 ℃; for 3.5h; lipase from Candida cylindracea;

DOI:10.1016/0957-4166(94)80080-4

Reference yield: 53.0%

dimethyl methoxymalonate (5018-30-4) + benzyl alcohol (100-51-6,185532-71-2) → (-)-methoxy benzyl methyl malonate (138434-85-2,138434-89-6)

Guidance literature:

In hexane; at 40 ℃; for 3.5h; biosynthesis by lipase from Candida cylindracea;

DOI:10.1021/jo00030a004

Reference yield:

methanol (67-56-1) + dibenzyl 2-methoxymalonate (138434-87-4) → dimethyl methoxymalonate (5018-30-4) + (+)-methoxy benzyl methyl malonate (138434-85-2,138434-89-6) + (-)-methoxy benzyl methyl malonate (138434-85-2,138434-89-6)

Guidance literature:

In hexane; at 40 ℃; Title compound not separated from byproducts; lipase from Candida cylindracea; stopped at 50percent conversion;

DOI:10.1016/S0040-4020(01)89450-3

upstream raw materials:

methanol

dibenzyl 2-methoxymalonate

dimethyl methoxymalonate

benzyl alcohol

Refernces

• 1、 Gutman, Arie L.,Shkolnik, Eleonora,Shapira, Michal. "A CONVENIENT METHOD FOR ENZYMATIC BENZYL-ALKYL TRANSESTERIFICATION UNDER MILD NEUTRAL CONDITIONS". . p. 8775 - 8780. Retrieved 2007/10/02.