5-(2-thienylmethylene)-2,4-imidazolidinedione

Base Information

• Chemical Name: 5-(2-thienylmethylene)-2,4-imidazolidinedione
• CAS No.: 138610-40-9
• Molecular Formula: C₈H₆N₂O₂S
• Molecular Weight: 194.214
• Mol file: 138610-40-9.mol

Synonyms:

Chemical Property of 5-(2-thienylmethylene)-2,4-imidazolidinedione

Chemical Property:

• PSA: 86.44000
• LogP: 1.58600

Purity/Quality:

99% ^*data from raw suppliers

5-(2-Thienylmethylene)-2,4-Imidazolidinedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-thienylmethylene)-2,4-imidazolidinedione

There total 7 articles about 5-(2-thienylmethylene)-2,4-imidazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

thiophene-2-carbaldehyde (98-03-3) + 2,4-imidazolidinedione (461-72-3) → (5Z)-5-(thiophen-2-ylmethylene)imidazolidine-2,4-dione (138610-40-9)

Guidance literature:

With ammonium acetate; In acetic acid; at 120 ℃; for 16h;

DOI:10.3390/molecules26133796

Reference yield:

thiophene-2-carbaldehyde (98-03-3) → 5-thiophen-2-ylmethylene-imidazolidine-2,4-dione (89939-28-6,138610-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; acetic acid anhydride

2: aqueous NaOH

With sodium hydroxide; sodium acetate; acetic anhydride;

DOI:10.1039/jr9380002100

Reference yield:

thiophene-2-carbaldehyde (98-03-3) + 2,4-imidazolidinedione (461-72-3) → 5-thiophen-2-ylmethylene-imidazolidine-2,4-dione (89939-28-6,138610-40-9)

Guidance literature:

With sodium acetate;

upstream raw materials:

thiophene-2-carbaldehyde

2,4-imidazolidinedione

thiophene

5-diazouracil

Downstream raw materials:

5-thiophen-2-ylmethylene-imidazolidine-2,4-dione

rac-3-(2-thienyl)alanine

L-3-(2-thienyl)alanine

Refernces

• 1、 Alves Borges Leal, Antonio L.,Barreto, Humberto M.,Faillace, Martín S.,Muratori da Costa, Luciana,Peláez, Walter J.,Silva, Ana P.. "Sulfated and Oxygenated Imidazoline Derivatives: Synthesis, Antioxidant Activity and Light-Mediated Antibacterial Activity". . . Retrieved 2020/04/15.
• 2、 Thenmozhiyal, Jeyanthi Chinnappa,Wong, Peter Tsun-Hon,Chui, Wai-Keung. "Anticonvulsant Activity of Phenylmethylenehydantoins: A Structure-Activity Relationship Study". . p. 1527 - 1535. Retrieved 2007/10/03.