2-AMINO-6-(DIETHOXYMETHYL)-4(1H)-PYRIMIDINONE

Base Information

• Chemical Name: 2-AMINO-6-(DIETHOXYMETHYL)-4(1H)-PYRIMIDINONE
• CAS No.: 78711-26-9
• Molecular Formula: C₉H₁₅N₃O₃
• Molecular Weight: 213.236
• Mol file: 78711-26-9.mol

Synonyms:4(1H)-Pyrimidinone,2-amino-6-(diethoxymethyl)- (9CI);2-Amino-6-(diethoxymethyl)pyrimidin-4(3H)-one;NSC 115756;

Chemical Property of 2-AMINO-6-(DIETHOXYMETHYL)-4(1H)-PYRIMIDINONE

Chemical Property:

• Vapor Pressure: 0.000365mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 318.3 °C at 760 mmHg
• Flash Point: 146.3 °C
• PSA: 90.23000
• Density: 1.3 g/cm³
• LogP: 1.00490

Purity/Quality:

99% ^*data from raw suppliers

2-AMINO-6-(DIETHOXYMETHYL)-4(1H)-PYRIMIDINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6-(DIETHOXYMETHYL)-4(1H)-PYRIMIDINONE

There total 1 articles about 2-AMINO-6-(DIETHOXYMETHYL)-4(1H)-PYRIMIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) + ethyl 4,4-diethoxyacetoacetate (10495-09-7) → 2-amino-6-diethoxymethyl-3H-pyrimidin-4-one (78711-26-9)

Guidance literature:

In ethanol; for 18h; Heating / reflux;

Reference yield: 58.5%

2-amino-6-diethoxymethyl-3H-pyrimidin-4-one (78711-26-9) + acetic anhydride (108-24-7) → 2-acetamido-6-(diethoxymethyl)pyrimidin-4(3H)-one (78711-25-8)

Guidance literature:

for 4h; Heating;

DOI:10.1021/jm00142a025

Reference yield:

2-amino-6-diethoxymethyl-3H-pyrimidin-4-one (78711-26-9) → sulfanilic acid-(4-diethoxymethyl-6-methoxy-pyrimidin-2-ylamide)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃

2: methanol

3: pyridine

4: aqueous NaOH

With pyridine; methanol; sodium hydroxide; trichlorophosphate;

DOI:10.1021/ja01204a044

upstream raw materials:

diguanidine carbonate

ethyl 4,4-diethoxyacetoacetate

Downstream raw materials:

2-acetamido-6-(diethoxymethyl)pyrimidin-4(3H)-one

2-acetamido-6-formylpyrimidin-4(3H)-one

N-acetyl-sulfanilic acid-(4-diethoxymethyl-6-methoxy-pyrimidin-2-ylamide)

Refernces