3-Acetyl-2-thiophenesulfonamide

Base Information

• Chemical Name: 3-Acetyl-2-thiophenesulfonamide
• CAS No.: 138890-88-7
• Molecular Formula: C6H7NO3S2
• Molecular Weight: 205.25500
• Mol file: 138890-88-7.mol

Synonyms:3-acetylthiophene-2-sulfonamide;methyl 3-acetyl-2-thiophenecarboxylate;3-acetyl-2-thiophenecarboxylic acid methyl ester;2-Thiophenecarboxylic acid,3-acetyl-,methyl ester;

Chemical Property of 3-Acetyl-2-thiophenesulfonamide

Chemical Property:

• Vapor Pressure: 5.19E-07mmHg at 25°C
• Boiling Point: 412.4oC at 760 mmHg
• Flash Point: 203.2oC
• PSA: 113.85000
• Density: 1.472g/cm3
• LogP: 2.37920

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Acetyl-2-thiophenesulfonamide

There total 2 articles about 3-Acetyl-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-thiophene-2-sulfonamide (138890-87-6) → 3-Acetylthiophene-2-sulfonamide (138890-88-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 1h; Reflux;

Reference yield: 79.0%

3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-thiophene-2-sulfonamide (138890-87-6) + sodium hydrogencarbonate (144-55-8) → 3-Acetylthiophene-2-sulfonamide (138890-88-7)

Guidance literature:

In tetrahydrofuran; hydrogenchloride;

Reference yield: 72.0%

3-Acetylthiophene-2-sulfonamide (138890-88-7) → 3-(2-bromoacetyl)thiophene-2-sulfonamide (154127-28-3)

Guidance literature:

3-Acetylthiophene-2-sulfonamide; With toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 0.5h;

With N-Bromosuccinimide; In acetonitrile; for 2h; Heating / reflux;

upstream raw materials:

3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-thiophene-2-sulfonamide

sodium hydrogencarbonate

Downstream raw materials:

3,4-dihydro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide

3-(2-bromoacetyl)thiophene-2-sulfonamide

Refernces

• 1、 -. "Process for the preparation of (R)-(+)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide.". Page/Page column 11. . Retrieved 2010/02/17.
• 2、 -. "Carbonic anhydrase inhibitors". . . Retrieved 2008/06/13.