4,4'-Dihydroxydiphenyl ether

Base Information

• Chemical Name: 4,4'-Dihydroxydiphenyl ether
• CAS No.: 1965-09-9
• Molecular Formula: C12H10O3
• Molecular Weight: 202.21
• Hs Code.: 29095000
• European Community (EC) Number: 217-809-1
• UNII: 7L83KGH26S
• DSSTox Substance ID: DTXSID8022169
• Nikkaji Number: J47.623D
• Wikidata: Q27268509
• ChEMBL ID: CHEMBL147060
• Mol file: 1965-09-9.mol

Synonyms:4,4'-Dihydroxydiphenyl ether;4,4'-Oxydiphenol;1965-09-9;4-(4-hydroxyphenoxy)phenol;Phenol, 4,4'-oxybis-;4,4-oxydiphenol;p,p'-Oxydiphenol;PHENOL, 4,4'-OXYDI-;Bis(4-hydroxyphenyl) ether;p-Hydroxyphenyl ether;quinol ether;p,p'-Oxybisphenol;4,4'-Dihydroxydiphenyl oxide;4,4'-Oxybisphenol;Bis(p-hydroxyphenyl) ether;p-(p-Hydroxyphenoxy)phenol;7L83KGH26S;KUC106452N;EINECS 217-809-1;MFCD00016463;KSC-19-056;BRN 1875320;4,4'-oxybis(phenol);4,4'-Oxybis[phenol];4,4'-oxybiphenol;bis(4-hydroxyphenyl)ether;4,4-Dihydroxydiphenyl ether;UNII-7L83KGH26S;4-(4-oxidanylphenoxy)phenol;SCHEMBL18198;4,4`-dihydroxydiphenyl ether;cid_16069;PHENOL, P,P'-OXYDI-;PHENOL, P,P'-OXYBIS-;4,4/'-Dihydroxydiphenyl ether;CHEMBL147060;DTXSID8022169;BDBM76095;Phenol, 4-(4-hydroxy)phenoxy-;AKOS003632505;CGA-195935;AS-17667;SY004829;US9688816, C;LS-105021;D2121;H10694;EN300-7386277;3-06-00-04408 (Beilstein Handbook Reference);A813854;4,4 inverted exclamation mark -Dihydroxydiphenyl Ether;Q27268509

Chemical Property of 4,4'-Dihydroxydiphenyl ether

Chemical Property:

• Appearance/Colour: off-white amorphous powder
• Melting Point: 163-168 °C
• Refractive Index: 1.5430 (estimate)
• Boiling Point: 379.24 °C at 760 mmHg
• PKA: 9.90±0.15(Predicted)
• Flash Point: 183.158 °C
• PSA: 49.69000
• Density: 1.289 g/cm³
• LogP: 2.89010
• Storage Temp.: Room Temperature
• Solubility.: DMSO (Sparingly), Methanol (Slightly)
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.062994177
• Heavy Atom Count: 15
• Complexity: 159

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,4'-Dihydroxydiphenyl Ether ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1O)OC2=CC=C(C=C2)O

Technology Process of 4,4'-Dihydroxydiphenyl ether

There total 22 articles about 4,4'-Dihydroxydiphenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4,4'-dibromodiphenyl ether (2050-47-7) → 4,4'-dihydroxydiphenyl ether (1965-09-9)

Guidance literature:

4,4'-dibromodiphenyl ether; With N,N′-bis(2,4,6-trimethylphenyl)oxalamide; acetophenone; sodium hydroxide; In dimethyl sulfoxide; at 130 ℃; for 7h;

With carbon dioxide; pyrographite; at 80 ℃; for 3h; pH=9; Reagent/catalyst; pH-value;

Reference yield: 81.2%

4,4'-oxydiphenylene diamine (101-80-4,121509-79-3) → 4,4'-dihydroxydiphenyl ether (1965-09-9)

Guidance literature:

4,4'-oxydiphenylene diamine; With sulfuric acid; sodium nitrite; at 0 ℃;

With sulfuric acid; In nitrobenzene; at 130 ℃; for 0.666667h; Temperature; Solvent;

Reference yield: 71.0%

D-(-)-quinic acid (77-95-2) → 4,4'-dihydroxydiphenyl ether (1965-09-9) + hydroquinone (123-31-9,8027-02-9)

Guidance literature:

With Amberlyst-15; air; In toluene; at 100 ℃; for 24h; Reagent/catalyst; Solvent; Temperature; Time;

DOI:10.1002/ejoc.201600616

upstream raw materials:

4,4'-dichlorodiphenyl ether

bis(4-methoxyphenyl) ether

4,4'-dibromodiphenyl ether

4,4'-oxydiphenylene diamine

Downstream raw materials:

4-[4-(6-bromo-hexyloxy)-phenoxy]-phenol

NSC₄₀₂₃₂₁

bis-(4-allyloxy-phenyl)-ether

bis-(4-carboxymethoxy-phenyl)-ether

Refernces

• 1、 -. "Aryl phenol compound as well as synthesis method and application thereof". Paragraph 0201-0204. . Retrieved 2021/05/12.
• 2、 -. "Industrial preparation method of 4, 4 '-dibromo diphenyl ether and 4, 4'-dihydroxy diphenyl ether". Paragraph 0059-0062. . Retrieved 2020/08/29.